Evidence map›Paper›PMID 36986765›Full record

ArticlePharmaceutics2023

Emetic Tartar-Loaded Liposomes as a New Strategy for Leishmaniasis Treatment.

Larissa D Coelho, Mirna M D Souza, Geovanni D Cassali, Raphaela A Silva, Maria J N Paiva, André L B Barros, Eliane M Teixeira, Josianne N Silveira, Paulo M Z Coelho, Marta M G Aguiar and 1 more

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Larissa D CoelhoDepartment of Pharmaceutical Products, Faculty of Pharmacy, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil.ORCID 0000-0002-4119-8696
Mirna M D SouzaDepartment of Clinical and Toxicological Analysis, Faculty of Pharmacy, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil.
Geovanni D CassaliDepartment of General Pathology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil.
Raphaela A SilvaDepartment of Pharmaceutical Products, Faculty of Pharmacy, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil.
Maria J N PaivaDepartment of Clinical and Toxicological Analysis, Faculty of Pharmacy, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil.
André L B BarrosDepartment of Clinical and Toxicological Analysis, Faculty of Pharmacy, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil.ORCID 0000-0002-7641-6585
Eliane M TeixeiraClinical Research and Public Policy Group on Infectious and Parasitic Diseases, René Rachou Institute, Fundação Oswaldo Cruz-FIOCRUZ, Belo Horizonte 30190-009, MG, Brazil.
Josianne N SilveiraDepartment of Clinical and Toxicological Analysis, Faculty of Pharmacy, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil.
Paulo M Z CoelhoRene Rachou Institute, Oswaldo Cruz Foundation (FIOCRUZ), Belo Horizonte 30190-009, MG, Brazil.
Marta M G AguiarDepartment of Pharmaceutical Products, Faculty of Pharmacy, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil.ORCID 0000-0002-3820-2842
Mônica C OliveiraDepartment of Pharmaceutical Products, Faculty of Pharmacy, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil.
Universidade Federal de Minas Gerais · BRFundação Oswaldo Cruz · BR

Funding

Fundação de Amparo à Pesquisa do Estado de Minas Gerais CDS-RED-00007-14-Rede Mineira de Pesquisas em NanobiotecnologiaNational Council for Scientific and Technological Development 307098/2018-4
6 · The paper itself

Abstract

Emetic tartar (ET), was used in the treatment of leishmaniasis but its use was discontinued due to its low therapeutic index. Liposomes have been shown to be a promising strategy for delivery of bioactive substances in the region of interest, in order to reduce and/or eliminate undesirable effects. In the present study, liposomes containing ET were prepared and characterized to evaluate acute toxicity as well as their leishmanicidal action using BALB/c mice with an inoculum of

Indexed as

acute toxicityantileishmanial efficacyemetic tartarliposomesvisceral leishmaniasis

Identifiers

PMID36986765
PMCPMC10056186
OpenAlexW4324057838

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.