Evidence map›Paper›PMID 36986732›Full record

ArticlePharmaceutics2023

Functionalization of 3D-Printed Titanium Scaffolds with Elastin-like Recombinamers to Improve Cell Colonization and Osteoinduction.

Jordi Guillem-Marti, Elia Vidal, Alessandra Girotti, Aina Heras-Parets, Diego Torres, Francisco Javier Arias, Maria-Pau Ginebra, Jose Carlos Rodriguez-Cabello, Jose Maria Manero

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Jordi Guillem-MartiBiomaterials, Biomechanics and Tissue Engineering (BBT), Department of Materials Science and Engineering (CEM), Universitat Politècnica de Catalunya-BarcelonaTech (UPC), 08019 Barcelona, Spain.ORCID 0000-0003-0307-2221
Elia VidalBiomaterials, Biomechanics and Tissue Engineering (BBT), Department of Materials Science and Engineering (CEM), Universitat Politècnica de Catalunya-BarcelonaTech (UPC), 08019 Barcelona, Spain.
Alessandra GirottiSmart Devices for NanoMedicine Group, Department of Biochemistry and Molecular Biology and Physiology, University of Valladolid, 47011 Valladolid, Spain.ORCID 0000-0003-4754-7022
Aina Heras-ParetsBiomaterials, Biomechanics and Tissue Engineering (BBT), Department of Materials Science and Engineering (CEM), Universitat Politècnica de Catalunya-BarcelonaTech (UPC), 08019 Barcelona, Spain.
Diego TorresBiomaterials, Biomechanics and Tissue Engineering (BBT), Department of Materials Science and Engineering (CEM), Universitat Politècnica de Catalunya-BarcelonaTech (UPC), 08019 Barcelona, Spain.
Francisco Javier AriasSmart Devices for NanoMedicine Group, Department of Biochemistry and Molecular Biology and Physiology, University of Valladolid, 47011 Valladolid, Spain.ORCID 0000-0001-8584-3768
Maria-Pau GinebraBiomaterials, Biomechanics and Tissue Engineering (BBT), Department of Materials Science and Engineering (CEM), Universitat Politècnica de Catalunya-BarcelonaTech (UPC), 08019 Barcelona, Spain.ORCID 0000-0002-4700-5621
Jose Carlos Rodriguez-CabelloBIOFORGE (Group for Advanced Materials and Nanobiotechnology), Centro de Investigación Biomédica en Red-Bioingeniería, Biomedicina y Nanomedicina (CIBER-BBN), University of Valladolid, 47011 Valladolid, Spain.
Jose Maria ManeroBiomaterials, Biomechanics and Tissue Engineering (BBT), Department of Materials Science and Engineering (CEM), Universitat Politècnica de Catalunya-BarcelonaTech (UPC), 08019 Barcelona, Spain.ORCID 0000-0002-1673-4389
Universitat Politècnica de Catalunya · ESUniversidad de Valladolid · ESInstitute for Bioengineering of Catalonia · ES

Funding

Institució Catalana de Recerca i Estudis Avançats Academia AwardMinistry of Science and Innovation, Spain DTS19/00162Ministry of Science and Innovation, Spain PID2019-106386RB-I00Ministry of Science and Innovation, Spain PID2021-125150OB-I00
6 · The paper itself

Abstract

The 3D printing of titanium (Ti) offers countless possibilities for the development of personalized implants with suitable mechanical properties for different medical applications. However, the poor bioactivity of Ti is still a challenge that needs to be addressed to promote scaffold osseointegration. The aim of the present study was to functionalize Ti scaffolds with genetically modified elastin-like recombinamers (ELRs), synthetic polymeric proteins containing the elastin epitopes responsible for their mechanical properties and for promoting mesenchymal stem cell (MSC) recruitment, proliferation, and differentiation to ultimately increase scaffold osseointegration. To this end, ELRs containing specific cell-adhesive (RGD) and/or osteoinductive (SN

Indexed as

3D printingelastin-like recombinamersfunctionalizationosseointegrationtitanium

Identifiers

PMID36986732
PMCPMC10055514
OpenAlexW4323568480

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.