Evidence map›Paper›PMID 36986684›Full record

ArticlePharmaceutics2023

A Validated Chiral LC-MS/MS Method for the Enantioselective Determination of (S)-(+)- and (R)-(-)-Ibuprofen in Dog Plasma: Its Application to a Pharmacokinetic Study.

Sanghee Choi, Wang-Seob Shim, Jiyoung Yoon, Doowon Choi, Jinseong Lee, Soo-Heui Paik, Eun-Kyoung Chung, Kyung-Tae Lee

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.2field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Sanghee ChoiDepartment of Biomedical and Pharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.ORCID 0000-0001-6223-4329
Wang-Seob ShimKyung Hee Drug Analysis Center, College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea.ORCID 0000-0002-0903-1386
Jiyoung YoonDepartment of Biomedical and Pharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.ORCID 0000-0001-6861-6600
Doowon ChoiDepartment of Biomedical and Pharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.
Jinseong LeeDepartment of BD&RA Division, BNC KOREA Inc., Seoul 06296, Republic of Korea.
Soo-Heui PaikCollege of Pharmacy, Sunchon National University, Suncheon-si 57922, Republic of Korea.
Eun-Kyoung ChungDepartment of Pharmacy, College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea.ORCID 0000-0001-9200-2799
Kyung-Tae LeeDepartment of Biomedical and Pharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.ORCID 0000-0002-3141-3727
Kyung Hee University · KRSunchon National University · KR

Funding

BNC Korea Co., Ltd. BNC-017
6 · The paper itself

Abstract

The purpose of this study was to develop a method for simultaneously separating ibuprofen enantiomers using electrospray ionization (ESI) liquid chromatography with tandem mass spectrometry (LC-MS/MS). LC-MS/MS was operated with negative ionization and multiple reaction monitoring modes; transitions were monitored at

Indexed as

beagle dog plasmabioanalytical method validationdexibuprofenenantiomeribuprofenLC–MS/MSpharmacokineticsvalidation

Identifiers

PMID36986684
PMCPMC10051808
OpenAlexW4323043919

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.