Evidence map›Paper›PMID 36986618›Full record

ArticlePharmaceutics2023

Insights into the Safety and Versatility of 4D Printed Intravesical Drug Delivery Systems.

Marco Uboldi, Cristiana Perrotta, Claudia Moscheni, Silvia Zecchini, Alessandra Napoli, Chiara Castiglioni, Andrea Gazzaniga, Alice Melocchi, Lucia Zema

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Marco UboldiSezione di Tecnologia e Legislazione Farmaceutiche "Maria Edvige Sangalli", Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, via Giuseppe Colombo 71, 20133 Milano, Italy.ORCID 0000-0003-0179-2233
Cristiana PerrottaDipartimento di Scienze Biomediche e Cliniche, Università degli Studi di Milano, via Giovanni Battista Grassi 74, 20157 Milano, Italy.ORCID 0000-0001-6680-4536
Claudia MoscheniDipartimento di Scienze Biomediche e Cliniche, Università degli Studi di Milano, via Giovanni Battista Grassi 74, 20157 Milano, Italy.ORCID 0000-0001-6614-665X
Silvia ZecchiniDipartimento di Scienze Biomediche e Cliniche, Università degli Studi di Milano, via Giovanni Battista Grassi 74, 20157 Milano, Italy.ORCID 0000-0001-6416-327X
Alessandra NapoliDipartimento di Scienze Biomediche e Cliniche, Università degli Studi di Milano, via Giovanni Battista Grassi 74, 20157 Milano, Italy.ORCID 0000-0001-9691-4103
Chiara CastiglioniDipartimento di Chimica, Materiali e Ingegneria Chimica "Giulio Natta", Politecnico di Milano, piazza Leonardo da Vinci 32, 20133 Milan, Italy.ORCID 0000-0002-6945-9157
Andrea GazzanigaSezione di Tecnologia e Legislazione Farmaceutiche "Maria Edvige Sangalli", Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, via Giuseppe Colombo 71, 20133 Milano, Italy.
Alice MelocchiSezione di Tecnologia e Legislazione Farmaceutiche "Maria Edvige Sangalli", Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, via Giuseppe Colombo 71, 20133 Milano, Italy.ORCID 0000-0001-5602-3314
Lucia ZemaSezione di Tecnologia e Legislazione Farmaceutiche "Maria Edvige Sangalli", Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, via Giuseppe Colombo 71, 20133 Milano, Italy.ORCID 0000-0001-8405-226X
University of Milan · ITPolitecnico di Milano · IT

Funding

Università degli Studi di Milano Linea 3 - Bando Straordinario per Progetti Interdipartimentali (Bando SEED2019)
6 · The paper itself

Abstract

This paper focuses on recent advancements in the development of 4D printed drug delivery systems (DDSs) for the intravesical administration of drugs. By coupling the effectiveness of local treatments with major compliance and long-lasting performance, they would represent a promising innovation for the current treatment of bladder pathologies. Being based on a shape-memory pharmaceutical-grade polyvinyl alcohol (PVA), these DDSs are manufactured in a bulky shape, can be programmed to take on a collapsed one suitable for insertion into a catheter and re-expand inside the target organ, following exposure to biological fluids at body temperature, while releasing their content. The biocompatibility of prototypes made of PVAs of different molecular weight, either uncoated or coated with Eudragit

Indexed as

3D printingcontrolled releasecytotoxicityfused deposition modelinglocal deliveryretentive systemsshape memory polymers

Identifiers

PMID36986618
PMCPMC10057729
OpenAlexW4321787388

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.