Evidence map›Paper›PMID 36986594›Full record

ArticlePharmaceutics2023

HER2-Specific Peptide (LTVSPWY) and Antibody (Herceptin) Targeted Core Cross-Linked Micelles for Breast Cancer: A Comparative Study.

Nazende Nur Bayram, Gizem Tuğçe Ulu, Nusaibah Abdulsalam Abdulhadi, Seda Gürdap, İsmail Alper İşoğlu, Yusuf Baran, Sevil Dinçer İşoğlu

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Nazende Nur BayramDepartment of Bioengineering, Faculty of Life and Natural Sciences, Abdullah Gül University, 38080 Kayseri, Turkey.
Gizem Tuğçe UluMolecular Biology and Genetics, Faculty of Science, İzmir Institute of Technology, 35433 İzmir, Turkey.ORCID 0000-0001-9265-9985
Nusaibah Abdulsalam AbdulhadiMolecular Biology and Genetics, Faculty of Science, İzmir Institute of Technology, 35433 İzmir, Turkey.ORCID 0000-0002-0926-9052
Seda GürdapDepartment of Bioengineering, Faculty of Life and Natural Sciences, Abdullah Gül University, 38080 Kayseri, Turkey.
İsmail Alper İşoğluDepartment of Bioengineering, Faculty of Life and Natural Sciences, Abdullah Gül University, 38080 Kayseri, Turkey.
Yusuf BaranMolecular Biology and Genetics, Faculty of Science, İzmir Institute of Technology, 35433 İzmir, Turkey.
Sevil Dinçer İşoğluDepartment of Bioengineering, Faculty of Life and Natural Sciences, Abdullah Gül University, 38080 Kayseri, Turkey.
Abdullah Gül University · TRIzmir Institute of Technology · TR

Funding

Scientific and Technological Research Council of Turkey 216S639
6 · The paper itself

Abstract

This study aims to prepare a novel breast cancer-targeted micelle-based nanocarrier, which is stable in circulation, allowing intracellular drug release, and to investigate its cytotoxicity, apoptosis, and cytostatic effects, in vitro. The shell part of the micelle is composed of zwitterionic sulfobetaine ((N-3-sulfopropyl-N,N-dimethylamonium)ethyl methacrylate), while the core part is formed by another block, consisting of AEMA (2-aminoethyl methacrylamide), DEGMA (di(ethylene glycol) methyl ether methacrylate), and a vinyl-functionalized, acid-sensitive cross-linker. Following this, a targeting agent (peptide (LTVSPWY) and antibody (Herceptin

Indexed as

breast cancerHER2human epidermal growth factor receptor 2 targetingstable micellesthe antitumor effect

Identifiers

PMID36986594
PMCPMC10053834
OpenAlexW4321598135

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.