Evidence map›Paper›PMID 36986525›Full record

ArticlePharmaceuticals (Basel, Switzerland)2023

Exploring Probenecid Derived 1,3,4-Oxadiazole-Phthalimide Hybrid as α-Amylase Inhibitor: Synthesis, Structural Investigation, and Molecular Modeling.

Bilal Ahmad Khan, Syeda Shamila Hamdani, Muhammad Khalid, Muhammad Ashfaq, Khurram Shahzad Munawar, Muhammad Nawaz Tahir, Ataualpa A C Braga, Ahmed M Shawky, Alaa M Alqahtani, Mohammed A S Abourehab and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 5 countries.

Bilal Ahmad KhanDepartment of Chemistry, The University of Azad Jammu and Kashmir, Muzaffarabad 13100, Pakistan.ORCID 0000-0002-7648-7359
Syeda Shamila HamdaniDepartment of Chemistry, The University of Azad Jammu and Kashmir, Muzaffarabad 13100, Pakistan.
Muhammad KhalidInstitute of Chemistry, Khwaja Fareed University of Engineering & Information Technology, Rahim Yar Khan 64200, Pakistan.
Muhammad AshfaqDepartment of Physics, University of Sargodha, Punjab 40100, Pakistan.ORCID 0000-0001-6663-8777
Khurram Shahzad MunawarInstitute of Chemistry, University of Sargodha, Sargodha 40100, Pakistan.ORCID 0000-0001-9055-2519
Muhammad Nawaz TahirDepartment of Physics, University of Sargodha, Punjab 40100, Pakistan.ORCID 0000-0002-6815-9806
Ataualpa A C BragaDepartamento de Química Fundamental, Instituto de Química, Universidade de São Paulo, Av. Prof. Lineu Prestes 748, São Paulo 05508-000, Brazil.ORCID 0000-0001-7392-3701
Ahmed M ShawkyScience and Technology Unit (STU), Umm Al-Qura University, Makkah 21955, Saudi Arabia.ORCID 0000-0002-3035-661X
Alaa M AlqahtaniPharmaceutical Chemistry Department, College of Pharmacy, Umm Al-Qura University, Makkah 21955, Saudi Arabia.ORCID 0000-0002-8845-2786
Mohammed A S AbourehabDepartment of Pharmaceutics, College of Pharmacy, Umm Al-Qura University, Makkah 21955, Saudi Arabia.ORCID 0000-0003-1348-6567
Gamal A GabrDepartment of Pharmacology and Toxicology, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia.ORCID 0000-0002-5028-9952
Mahmoud A A IbrahimComputational Chemistry Laboratory, Chemistry Department, Faculty of Science, Minia University, Minia 61519, Egypt.ORCID 0000-0003-4819-2040
Peter A SidhomDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University, Tanta 31527, Egypt.ORCID 0000-0003-2579-6351
Umm al-Qura University · SAUniversity of Sargodha · PKUniversity of Azad Jammu and Kashmir · PKKhwaja Fareed University of Engineering and Information Technology · PKMinia University · EGPrince Sattam Bin Abdulaziz University · SATanta University · EGUniversidade de São Paulo · BR

Funding

Higher Education Commission NRPU-6455Umm al-Qura University 22UQU4290565DSR11
6 · The paper itself

Abstract

1,3,4-Oxadiazole moiety is a crucial pharmacophore in many biologically active compounds. In a typical synthesis, probenecid was subjected to a sequence of reactions to obtain a 1,3,4-oxadiazole-phthalimide hybrid (

Indexed as

DFT calculationsmolecular dockingoxadiazoleX-ray diffractionα-amylase inhibition

Identifiers

PMID36986525
PMCPMC10051969
OpenAlexW4324064539

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.