Evidence map›Paper›PMID 36986491›Full record

ReviewPharmaceuticals (Basel, Switzerland)2023

Current Trends in Neoantigen-Based Cancer Vaccines.

Szu-Ying Ho, Che-Mai Chang, Hsin-Ni Liao, Wan-Hsuan Chou, Chin-Lin Guo, Yun Yen, Yusuke Nakamura, Wei-Chiao Chang

Open access · goldAbstract readReview
In one paragraph

Review in Pharmaceuticals (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Szu-Ying HoDepartment of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, Taipei City 110, Taiwan.
Che-Mai ChangDepartment of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, Taipei City 110, Taiwan.ORCID 0000-0002-0353-9744
Hsin-Ni LiaoDepartment of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, Taipei City 110, Taiwan.
Wan-Hsuan ChouDepartment of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, Taipei City 110, Taiwan.ORCID 0000-0002-7693-5959
Chin-Lin GuoInstitute of Physics, Academia Sinica, Taipei City 115, Taiwan.ORCID 0000-0002-8055-9482
Yun YenPh.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei City 110, Taiwan.ORCID 0000-0003-0815-412X
Yusuke NakamuraCancer Precision Medicine Center, Japanese Foundation for Cancer Research, Tokyo 135-8550, Japan.
Wei-Chiao ChangDepartment of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, Taipei City 110, Taiwan.
Taipei Medical University · TWInstitute of Physics, Academia Sinica · TWNational Institute of Biomedical Innovation, Health and Nutrition · JPWan Fang Hospital · TW

Funding

National Science and Technology Council Taiwan MOST 111-2628-B-038-025
6 · The paper itself

Abstract

Cancer immunotherapies are treatments that use drugs or cells to activate patients' own immune systems against cancer cells. Among them, cancer vaccines have recently been rapidly developed. Based on tumor-specific antigens referred to as neoantigens, these vaccines can be in various forms such as messenger (m)RNA and synthetic peptides to activate cytotoxic T cells and act with or without dendritic cells. Growing evidence suggests that neoantigen-based cancer vaccines possess a very promising future, yet the processes of immune recognition and activation to relay identification of a neoantigen through the histocompatibility complex (MHC) and T-cell receptor (TCR) remain unclear. Here, we describe features of neoantigens and the biological process of validating neoantigens, along with a discussion of recent progress in the scientific development and clinical applications of neoantigen-based cancer vaccines.

Indexed as

cancer neoantigenimmune systemneoantigen vaccineT-cell response

Identifiers

PMID36986491
PMCPMC10056833
OpenAlexW4323314024

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.