ArticlePharmaceuticals (Basel, Switzerland)2023
Valorization of
Article in Pharmaceuticals (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- The Versatility of Pomegranate: From Phytochemical Diversity to Antimicrobial and Translational Applications.Microorganisms · 2026Review
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- Antiparasitic Potential of Bioactive Compounds FromJournal of parasitology research · 2026Review
- Integrated profiling of essential metals, phenolic compounds, anti-inflammatory and hydroxyl radical scavenging activities for five medicinal plants.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025Article
- Comparative antioxidant activity of pomegranate leaf extract and derived metabolites in single and co-cultured cell lines.Scientific reports · 2025Article
- Antinociceptive, anti-inflammatory, and antiophidic potential of Punica granatum leaves extract and fraction: an in vitro and in vivo evaluation.Inflammopharmacology · 2025Article
- Phytochemical Analysis and Therapeutic Potential ofPlants (Basel, Switzerland) · 2025Article
- Effect of Punicalagin and Ellagic Acid on Human Fibroblasts In Vitro: A Preliminary Evaluation of Their Therapeutic Potential.Nutrients · 2023Article
- Exploring the Potential of Extracts fromPharmaceuticals (Basel, Switzerland) · 2023Article
- The Bioactive Properties of Carotenoids from LipophilicMolecules (Basel, Switzerland) · 2023Article
- Argentatin Content in Guayule Leaves (Plants (Basel, Switzerland) · 2023Article
- Comparative analysis of the phenolic contents and antioxidant activities of different parts of two pomegranate (Frontiers in plant science · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Due to a lack of innovative valorization strategies, pomegranate processing generates a significant amount of residues with a negative environmental footprint. These by-products are a rich source of bioactive compounds with functional and medicinal benefits. This study reports the valorization of pomegranate leaves as a source of bioactive ingredients using maceration, ultrasound, and microwave-assisted extraction techniques. The phenolic composition of the leaf extracts was analyzed using an HPLC-DAD-ESI/MSn system. The extracts' antioxidant, antimicrobial, cytotoxic, anti-inflammatory, and skin-beneficial properties were determined using validated in vitro methodologies. The results showed that gallic acid, (-)-epicatechin, and granatin B were the most abundant compounds in the three hydroethanolic extracts (between 0.95 and 1.45, 0.7 and 2.4, and 0.133 and 3.0 mg/g, respectively). The leaf extracts revealed broad-spectrum antimicrobial effects against clinical and food pathogens. They also presented antioxidant potential and cytotoxic effects against all tested cancer cell lines. In addition, tyrosinase activity was also verified. The tested concentrations (50-400 µg/mL) ensured a cellular viability higher than 70% in both keratinocyte and fibroblast skin cell lines. The obtained results indicate that the pomegranate leaves could be used as a low-cost source of value-added functional ingredients for potential nutraceutical and cosmeceutical applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.