Evidence map›Paper›PMID 36986420›Full record

ArticlePathogens (Basel, Switzerland)2023

Synergistic Detrimental Effects of Cigarette Smoke, Alcohol, and SARS-CoV-2 in COPD Bronchial Epithelial Cells.

Abenaya Muralidharan, Christopher D Bauer, Dawn M Katafiasz, Heather M Strah, Aleem Siddique, St Patrick Reid, Kristina L Bailey, Todd A Wyatt

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathogens (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Sex-Specific Multimorbidity-Multibehaviour Patterns in Primary Care Populations.International journal of environmental research and public health · 2025
    Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Abenaya MuralidharanDepartment of Pathology and Microbiology, College of Medicine, The University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0003-4065-3922
Christopher D BauerPulmonary, Critical Care, and Sleep Medicine Division, Department of Internal Medicine, College of Medicine, the University of Nebraska Medical Center, Omaha, NE 68198, USA.
Dawn M KatafiaszPulmonary, Critical Care, and Sleep Medicine Division, Department of Internal Medicine, College of Medicine, the University of Nebraska Medical Center, Omaha, NE 68198, USA.
Heather M StrahPulmonary, Critical Care, and Sleep Medicine Division, Department of Internal Medicine, College of Medicine, the University of Nebraska Medical Center, Omaha, NE 68198, USA.
Aleem SiddiqueDepartment of Surgery, College of Medicine, the University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0001-8425-1293
St Patrick ReidDepartment of Pathology and Microbiology, College of Medicine, The University of Nebraska Medical Center, Omaha, NE 68198, USA.
Kristina L BaileyPulmonary, Critical Care, and Sleep Medicine Division, Department of Internal Medicine, College of Medicine, the University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0003-2990-9042
Todd A WyattPulmonary, Critical Care, and Sleep Medicine Division, Department of Internal Medicine, College of Medicine, the University of Nebraska Medical Center, Omaha, NE 68198, USA.
University of Nebraska Medical Center · USVA Nebraska Western Iowa Health Care System · US

Funding

The Role of TP-R on Alcohol-Induced Multi-Organ Damage: Liver and HeartP50AA030407 · NIAAA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Kusum K. Kharbanda · 2023 to 2026
$7.9M
Lung Innate COVID-19 Defense Specific to Veterans Risk CharacteristicsI01BX005413 · VA · OMAHA VA MEDICAL CENTER · PI BAILEY, KRISTINA L, WYATT, TODD A · 2021 to 2022
–
Reactive aldehydes and alcohol misuse in lung infectionsI01BX005886 · VA · OMAHA VA MEDICAL CENTER · PI WYATT, TODD A · 2023 to 2025
–
BLRD VA I01 BX005413BLRD VA I01 BX005886BLRD VA IK6 BX005962CIHR 202012MFE-458423-251980NIAAA NIH HHS P50 AA030407
6 · The paper itself

Abstract

Lung conditions such as COPD, as well as risk factors such as alcohol misuse and cigarette smoking, can exacerbate COVID-19 disease severity. Synergistically, these risk factors can have a significant impact on immunity against pathogens. Here, we studied the effect of a short exposure to alcohol and/or cigarette smoke extract (CSE) in vitro on acute SARS-CoV-2 infection of ciliated human bronchial epithelial cells (HBECs) collected from healthy and COPD donors. We observed an increase in viral titer in CSE- or alcohol-treated COPD HBECs compared to untreated COPD HBECs. Furthermore, we treated healthy HBECs accompanied by enhanced lactate dehydrogenase activity, indicating exacerbated injury. Finally, IL-8 secretion was elevated due to the synergistic damage mediated by alcohol, CSE, and SARS-CoV-2 in COPD HBECs. Together, our data suggest that, with pre-existing COPD, short exposure to alcohol or CSE is sufficient to exacerbate SARS-CoV-2 infection and associated injury, impairing lung defences.

Indexed as

alcoholcigarette smokingCOPDlung injurySARS-CoV-2

Identifiers

PMID36986420
PMCPMC10056639
OpenAlexW4353065021

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.