ReviewPathogens (Basel, Switzerland)2023
Enrichment of Acid-Associated Microbiota in the Saliva of Type 2 Diabetes Mellitus Adults: A Systematic Review.
Review in Pathogens (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- Association between Live Dietary Microbes and Root Caries: A Cross-Sectional Study with a Predictive Risk Model.Oral health & preventive dentistry · 2026Article
- Oral Microbiota and Type 2 Diabetes: Interactions, Potential Mechanisms, and Preventive Strategies.Microorganisms · 2026Review
- Oral microbiome classification of elevated salivary glucose in a large adolescent Kuwaiti population.Frontiers in microbiology · 2026Article
- SupragingivalJournal of oral microbiology · 2026Article
- The causal relationship between bacterial pneumonia and diabetes: a two-sample mendelian randomization study.Islets · 2024Article
- Salivary features of periodontitis and gingivitis in type 2 diabetes mellitus.Scientific reports · 2024Article
- Association of oral fungal profiles with health status and bacterial composition in elderly adults receiving community support and home care service.Applied and environmental microbiology · 2024Article
- A comparison of oral bacteriome isolated from periodontal pockets of participants with or without diabetes mellitus in Uganda: a case control study.BMC research notes · 2024Article
- Impact of HbA1c control and type 2 diabetes mellitus exposure on the oral microbiome profile in the elderly population.Journal of oral microbiology · 2024Article
- Lung Abscess Caused byInfection and drug resistance · 2023Article
- microBiomeGSM: the identification of taxonomic biomarkers from metagenomic data using grouping, scoring and modeling (G-S-M) approach.Frontiers in microbiology · 2023Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
It could conceivably be hypothesized that a link exists between an altered microbiota due to local hyperglycemia and the increased risk of caries in diabetes mellitus (DM). This systematic review aimed to perform a cross-study comparison into the salivary microbiota of adults with type 2 diabetes mellitus (T2D) compared to adults without T2D, particularly focusing on the abundance of acid-associated bacteria. This report follows PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses). Studies using next-generation sequencing and other molecular techniques are included. The methodological quality of individual studies was assessed using appropriate Joanna Briggs Institute tools. The certainty of the evidence considering the effect direction was evaluated using the GRADE approach. From 2060 titles retrieved, 12 were included in the data synthesis, totalling 873 individuals with T2D and controls evaluated across the literature. Weighted averages of blood glucose levels (HbA1c-fasting blood glucose) were 8.21%-172.14 mg/dL and 5.12%-84.53 mg/dL for T2D and controls, respectively. In most studies, the relative abundance of acidogenic and aciduric bacteria was higher in diabetics when compared to their normoglycaemic controls. Whilst the evidence certainty was very low, there was a consistent
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.