Evidence map›Paper›PMID 36986142›Full record

ArticleNutrients2023

Diet Quality, Microbial Lignan Metabolites, and Cardiometabolic Health among US Adults.

Nicholas A Koemel, Alistair M Senior, Tarik Benmarhnia, Andrew Holmes, Mirei Okada, Youssef Oulhote, Helen M Parker, Sanam Shah, Stephen J Simpson, David Raubenheimer and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Nicholas A KoemelCharles Perkins Centre, The University of Sydney, Sydney 2006, Australia.ORCID 0000-0002-5463-6894
Alistair M SeniorCharles Perkins Centre, The University of Sydney, Sydney 2006, Australia.
Tarik BenmarhniaScripps Institution of Oceanography, University of California, San Diego, CA 92093, USA.
Andrew HolmesCharles Perkins Centre, The University of Sydney, Sydney 2006, Australia.ORCID 0000-0002-7406-4387
Mirei OkadaCharles Perkins Centre, The University of Sydney, Sydney 2006, Australia.ORCID 0000-0002-9198-1128
Youssef OulhoteDepartment of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA 01003, USA.ORCID 0000-0002-2323-1982
Helen M ParkerCharles Perkins Centre, The University of Sydney, Sydney 2006, Australia.ORCID 0000-0002-3826-2765
Sanam Shah"Exposome and Heredity" Team, CESP, Paris-Saclay University, UVSQ, University Paris-Sud, Inserm, Gustave Roussy, F-94805 Villejuif, France.
Stephen J SimpsonCharles Perkins Centre, The University of Sydney, Sydney 2006, Australia.
David RaubenheimerCharles Perkins Centre, The University of Sydney, Sydney 2006, Australia.
Timothy P GillCharles Perkins Centre, The University of Sydney, Sydney 2006, Australia.
Nasser LaoualiScripps Institution of Oceanography, University of California, San Diego, CA 92093, USA.ORCID 0000-0002-8532-456X
Michael R SkiltonSydney Medical School, The University of Sydney, Sydney 2006, Australia.ORCID 0000-0003-2793-2388
The University of Sydney · AUScripps Institution of Oceanography · USInserm · FRUniversity of Massachusetts Amherst · US

Funding

l'Ecole Doctorale de Santé Publique, Ministère de l'enseignement supérieur, de la recherche et de l'innovation Doctoral ScholarshipNational Health and Medical Research Council GNT1149976The University of Sydney Faculty of Medicine and Health Executive Dean Stipend Scholarship
6 · The paper itself

Abstract

The gut microbiome has been shown to play a role in the relationship between diet and cardiometabolic health. We sought to examine the degree to which key microbial lignan metabolites are involved in the relationship between diet quality and cardiometabolic health using a multidimensional framework. This analysis was undertaken using cross-sectional data from 4685 US adults (age 43.6 ± 16.5 years; 50.4% female) participating in the National Health and Nutrition Examination Survey for 1999-2010. Dietary data were collected from one to two separate 24-hour dietary recalls and diet quality was characterized using the 2015 Healthy Eating Index. Cardiometabolic health markers included blood lipid profile, glycemic control, adiposity, and blood pressure. Microbial lignan metabolites considered were urinary concentrations of enterolignans, including enterolactone and enterodiol, with higher levels indicating a healthier gut microbial environment. Models were visually examined using a multidimensional approach and statistically analyzed using three-dimensional generalized additive models. There was a significant interactive association between diet quality and microbial lignan metabolites for triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, insulin, oral glucose tolerance, adiposity, systolic blood pressure, and diastolic blood pressure (all

Indexed as

Cardiovascular DiseasesLignansAdultCholesterol, HDLCross-Sectional StudiesDietFemaleHumansMaleMiddle AgedNutrition SurveysObesityRisk FactorsTriglyceridesCholesterol, HDLLignansTriglyceridescardiometabolic healthdiet qualityenterodiolenterolactonegut healthHealthy Eating IndexmicrobiomeNHANES

Identifiers

PMID36986142
PMCPMC10054147
OpenAlexW4324366097

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.