ArticleNutrients2023
Human Milk Oligosaccharides Are Associated with Lactation Stage and Lewis Phenotype in a Chinese Population.
Article in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 23 citations in OpenAlex.
- Decoding the HMO‒microbiome axis: bridging maternal milk to infant health outcomes.Gut microbes · 2026Review
- New Insights into Human Milk Oligosaccharide Profiles in China: Findings from a Large-Scale Analysis of Human Milk.Nutrients · 2026Article
- Dynamics and compositional profiles of human milk oligosaccharides in mothers with gestational diabetes mellitus across lactation.Frontiers in nutrition · 2026Article
- Longitudinal changes of human milk oligosaccharides in Japan and their associations with maternal or infant characteristics.Frontiers in nutrition · 2026Article
- Human milk oligosaccharide composition, concentrations and association with maternal factors in the multi-ethnic Asian GUSTO cohort.Frontiers in nutrition · 2026Article
- Characterization of human milk oligosaccharides from Chinese mothers and their association with delivery mode and infant eczema.Frontiers in nutrition · 2026Article
- Milk sialyl-oligosaccharides mediate the early colonization of gut commensal microbes in piglets.Microbiome · 2025Article
- A review of human milk oligosaccharide concentrations of breast milk for infants and young children through 24 months of age.Frontiers in pediatrics · 2025Review
- Absolute quantification of eight human milk oligosaccharides in breast milk to evaluate their concentration profiles and associations with infants' neurodevelopmental outcomes.Journal of food science · 2024Article
- Analysis of twelve human milk oligosaccharides over fifteen months post-partum in human milk from Chinese mothers.Heliyon · 2024Article
- Article
- Modifiable and Non-Modifiable Factors That Affect Human Milk Oligosaccharides Composition.Nutrients · 2024Review
- Recent advances of 3-fucosyllactose in health effects and production.Archives of microbiology · 2024Review
- Enhancement of motor neuron development and function in zebrafish by sialyllacto-N-tetraose b.Translational pediatrics · 2024Article
- Human Milk-The Biofluid That Nourishes Infants from the First Day of Life.Foods (Basel, Switzerland) · 2024Review
- Human milk microbiota and oligosaccharides in colostrum and mature milk: comparison and correlation.Frontiers in nutrition · 2024Article
- Human milk oligosaccharide profiles remain unaffected by maternal pre-pregnancy body mass index in an observational study.Frontiers in nutrition · 2024Article
- Lactational and geographical variation in the concentration of six oligosaccharides in Chinese breast milk: a multicenter study over 13 months postpartum.Frontiers in nutrition · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundHuman milk oligosaccharides (HMOs) are the third most abundant component of human milk. Various factors may affect the concentration of HMOs, such as the lactation period, Lewis blood type, and the maternal secretor gene status.
objectivesThe purpose of this study is to investigate factors associated with HMO concentrations in Chinese populations.
methodsA sub-sample of 481 was randomly selected from a large cross-sectional study in China (
resultsMedian total HMO concentration was 13.6 g/L, 10.7 g/L, and 6.0 g/L for colostrum, transitional milk, and mature milk, respectively. HMO concentration decreased significantly as the lactation period increased (
conclusionsThe concentration of HMOs changes throughout lactation, and it varies between different HMOs. HMO concentrations differed between lactation stage, maternal secretor gene status, Lewis blood type, volume of breast milk expressed, and the province the mother came from. Prematurity, mode of delivery, parity, infants' gender, and maternal characteristics did not affect the HMO concentration. Geographical region may be not associated with HMOs concentration in human milk. There may be a mechanism for co-regulation of the secretion of some of the oligosaccharides such as 2'FL vs. 3FL, 2'FL vs. LNnT, and lacto-N-tetraose (LNT).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.