Evidence map›Paper›PMID 36986110›Full record

ArticleNutrients2023

Introduction of Egg White and Yolk to Infant Diets and Early Childhood Atopic Dermatitis.

Man-Chin Hua, Tsung-Chieh Yao, Sui-Ling Liao, Ming-Han Tsai, Shen-Hao Lai, Li-Chen Chen, Kuan-Wen Su, Chih-Yung Chiu, Kuo-Wei Yeh, Jing-Long Huang

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Daily egg intake may reduce sensitisation to common allergenic foods among six- to nine-month-old south African infants: A randomized controlled trial.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025
    Trial
  3. Article
  4. Early Origins of Asthma and Allergies: Clues From Studies in China.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2025
    Review
  5. A two-sample Mendelian randomization study of mutual relations of six types of diets in atopic dermatitis.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Man-Chin HuaDepartment of Pediatrics, Chang Gung Memorial Hospital, Keelung 204, Taiwan.
Tsung-Chieh YaoCollege of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
Sui-Ling LiaoDepartment of Pediatrics, Chang Gung Memorial Hospital, Keelung 204, Taiwan.
Ming-Han TsaiDepartment of Pediatrics, Chang Gung Memorial Hospital, Keelung 204, Taiwan.
Shen-Hao LaiCollege of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
Li-Chen ChenCollege of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
Kuan-Wen SuDepartment of Pediatrics, Chang Gung Memorial Hospital, Keelung 204, Taiwan.
Chih-Yung ChiuCollege of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
Kuo-Wei YehCollege of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
Jing-Long HuangCollege of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
Chang Gung University · TWChang Gung Memorial Hospital · TW

Funding

Keelung Chang Gung Memorial Hospital CMRPG 2N0061, 2K0321-322, 2E0131-135, 2B0041-43
6 · The paper itself

Abstract

This study investigated whether the introduction of allergenic foods in infancy is associated with atopic dermatitis (AD) in early childhood. Information regarding parental allergic histories, the introduction of six possible allergenic foods (fruits, egg white, egg yolk, fish, shellfish, and peanuts), and physician-diagnosed AD was obtained using age-specific questionnaires (0-2 years). Immunoglobulin E, specific to 20 food allergens, was also quantified at 12 months of age. Logistic regression analyses were used to determine the association between individual food introduction and the outcomes of food sensitization and AD. We found AD development by 2 years of age was significantly related to a parental history of allergy (adjusted odds ratio (aOR) = 1.29) and not being introduced to egg white and yolk during infancy (aORs = 2.27 and 1.97, respectively). Stratified analyses revealed that the introduction of both egg white and yolk was negatively associated with AD by 2 years of age, especially for those children where both parents had allergic diseases (aOR = 0.10). In summary, the introduction of egg white and yolk to an infant's diet may be a modifiable factor in reducing the risk of physician-diagnosed AD by 2 years of age, which may be particularly important for infants where both parents have allergies.

Indexed as

Dermatitis, AtopicEgg HypersensitivityFood HypersensitivityAllergensAnimalsChild, PreschoolDietEgg WhiteHumansAllergensatopic dermatitischildrenegg whiteegg yolkfood sensitizationparental allergy

Identifiers

PMID36986110
PMCPMC10053911
OpenAlexW4324089684

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.