ArticleMolecules (Basel, Switzerland)2023
Alginate-Gelatin Self-Healing Hydrogel Produced via Static-Dynamic Crosslinking.
Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 29 citations in OpenAlex.
- Preparation and Application of Sodium Alginate-Based Composite Hydrogels in Wound Dressings.Gels (Basel, Switzerland) · 2026Review
- Polysaccharides self-healing hydrogel for skin regeneration.Journal of pharmaceutical analysis · 2026Review
- Natural Polymer-Based Mechanically Strong Hydrogel with Fast Self-Healing for Heavy Metal Ions Removal and Supercapacitor Applications.Polymers · 2026Article
- Crosslinker-Free, Printable Alginate-Boronic Acid Hydrogel Adhesive with Enhanced Mechanical Performance for Soft Tissue Fixation.Molecules (Basel, Switzerland) · 2026Article
- Self-healing hydrogels: mechanisms and applications in biomedical and environmental fields.Biodegradation · 2026Review
- Novel Alginate-Based Physical Hydrogels: Promising Cleaning Tools for Sensitive Artifacts.Polymers · 2025Article
- Efficacious biosorption of crystal violet pollutant dye from aqueous solutions via Padina pavonica derived alginate.Scientific reports · 2025Article
- Influence of Starch Cross-Linking on the Performance of Cellulose Aerogels for Oil Spills Sorption.Gels (Basel, Switzerland) · 2025Article
- Alginate-Gelatin Hydrogel Scaffold Model for Hypoxia Induction in Glioblastoma Embedded Spheroids.Gels (Basel, Switzerland) · 2025Article
- Hyaluronic Acid-Based Dynamic Hydrogels for Cartilage Repair and Regeneration.Gels (Basel, Switzerland) · 2024Review
- Therapeutic potential of endometrial stem cells encapsulated in alginate/gelatin hydrogel to treat of polycystic ovary syndrome.Regenerative therapy · 2024Article
- Evaluating cells metabolic activity of bioinks for bioprinting: the role of cell-laden hydrogels and 3D printing on cell survival.Frontiers in bioengineering and biotechnology · 2024Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Alginate-gelatin hydrogels mimicking extracellular matrix (ECM) of soft tissues have been generated by static-dynamic double crosslinking, allowing fine control over the physical and chemical properties. Dynamic crosslinking provides self-healing and injectability attributes to the hydrogel and promotes cell migration and proliferation, while the static network improves stability. The static crosslinking was performed by enzymatic coupling of the tyrosine residues of gelatin with tyramine residues inserted in the alginate backbone, catalyzed by horseradish peroxidase (HRP). The dynamic crosslinking was obtained by functionalizing alginate with 3-aminophenylboronic acid which generates a reversible bond with the vicinal hydroxyl groups of the alginate chains. Varying the ratio of alginate and gelatin, hydrogels with different properties were obtained, and the most suitable for 3D soft tissue model development with a 2.5:1 alginate:gelatin molar ratio was selected. The selected hydrogel was characterized with a swelling test, rheology test, self-healing test and by cytotoxicity, and the formulation resulted in transparent, reproducible, varying biomaterial batch, with a fast gelation time and cell biocompatibility. It is able to modulate the loss of the inner structure stability for a longer time with respect to the formulation made with only covalent enzymatic crosslinking, and shows self-healing properties.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.