Evidence map›Paper›PMID 36985680›Full record

ArticleMolecules (Basel, Switzerland)2023

Investigation of Newly Synthesized Bis-Acyl-Thiourea Derivatives of 4-Nitrobenzene-1,2-Diamine for Their DNA Binding, Urease Inhibition, and Anti-Brain-Tumor Activities.

Nasima Arshad, Uzma Parveen, Pervaiz Ali Channar, Aamer Saeed, Waseem Sharaf Saeed, Fouzia Perveen, Aneela Javed, Hammad Ismail, Muhammad Ismail Mir, Atteeque Ahmed and 2 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Synthesis, characterization,RSC advances · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 3 countries.

Nasima ArshadDepartment of Chemistry, Faculty of Sciences, Allama Iqbal Open University, Islamabad 44000, Pakistan.
Uzma ParveenDepartment of Chemistry, Faculty of Sciences, Allama Iqbal Open University, Islamabad 44000, Pakistan.
Pervaiz Ali ChannarDepartment of Basic Sciences and Humanities, Dawood University of Engineering and Technology, Karachi 74800, Pakistan.
Aamer SaeedDepartment of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan.
Waseem Sharaf SaeedRestorative Dental Sciences Department, College of Dentistry, King Saud University, Riyadh 11545, Saudi Arabia.ORCID 0000-0002-5254-5665
Fouzia PerveenSchool of Interdisciplinary Engineering and Sciences (SINES), National University of Sciences and Technology (NUST), Islamabad 44000, Pakistan.
Aneela JavedHealthcare Biotechnology Atta-ur-Rehman School of Applied Biosciences, National University of Sciences and Technology (NUST), Islamabad 44000, Pakistan.
Hammad IsmailDepartment of Biochemistry & Biotechnology, University of Gujrat, Gujrat 50700, Pakistan.ORCID 0000-0002-8008-4595
Muhammad Ismail MirDepartment of Chemistry, Faculty of Sciences, Allama Iqbal Open University, Islamabad 44000, Pakistan.ORCID 0000-0002-9799-6291
Atteeque AhmedDepartment of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan.
Basit AzadSchool of Interdisciplinary Engineering and Sciences (SINES), National University of Sciences and Technology (NUST), Islamabad 44000, Pakistan.
Ishaq KhanTexas A&M Health Science Center, Joe H. Reynolds Medical Build, College Station, TX 77843, USA.
Allama Iqbal Open University · PKNational University of Sciences and Technology · PKQuaid-i-Azam University · PKDawood University of Engineering and Technology · PKKing Saud University · SATexas A&M Health Science Center · USUniversity of Gujrat · PK

Funding

Waseem Sharaf Saeed, King Saud University, Riyadh, Saudi Arabia. Researchers Supporting Project number (RSPD2023R 755)
6 · The paper itself

Abstract

Bis-acyl-thiourea derivatives, namely

Indexed as

Brain NeoplasmsUreaseAnti-Bacterial AgentsDNAEnzyme InhibitorsHEK293 CellsHumansMolecular Docking SimulationNitrobenzenesStructure-Activity RelationshipThiourea4-nitrobenzene-1,2-diamineAnti-Bacterial AgentsDNAEnzyme InhibitorsNitrobenzenesThioureaUreaseanti-brain tumor activitybis-acyl-thioureaDFT/docking analysisspectral & electrochemical DNA bindingurease inhibition

Identifiers

PMID36985680
PMCPMC10051851
OpenAlexW4327715485

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.