Catalytic Asymmetric α-Functionalization of α-Branched Aldehydes.

Silvia Vera, Aitor Landa, Antonia Mielgo, Iñaki Ganboa, Mikel Oiarbide, Vadim Soloshonok

Abstract readReview

In one paragraph

Review in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Featured Reviews in Organic Chemistry.Molecules (Basel, Switzerland) · 2023
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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

6 authors.

Silvia VeraDepartment of Organic Chemistry I, University of the Basque Country UPV/EHU, Manuel Lardizabal 3, 20018 Donostia-San Sebastián, Spain.

Aitor LandaDepartment of Organic Chemistry I, University of the Basque Country UPV/EHU, Manuel Lardizabal 3, 20018 Donostia-San Sebastián, Spain.

Antonia MielgoDepartment of Organic Chemistry I, University of the Basque Country UPV/EHU, Manuel Lardizabal 3, 20018 Donostia-San Sebastián, Spain.

Iñaki GanboaDepartment of Organic Chemistry I, University of the Basque Country UPV/EHU, Manuel Lardizabal 3, 20018 Donostia-San Sebastián, Spain.

Mikel OiarbideDepartment of Organic Chemistry I, University of the Basque Country UPV/EHU, Manuel Lardizabal 3, 20018 Donostia-San Sebastián, Spain.ORCID 0000-0003-0362-0136

Vadim SoloshonokDepartment of Organic Chemistry I, University of the Basque Country UPV/EHU, Manuel Lardizabal 3, 20018 Donostia-San Sebastián, Spain.ORCID 0000-0003-0681-4526

Funding

Basque Government grant IT-1583-22MCIN/AEI/10.13039/501100011033 PID2019-109633GB-C21

6 · The paper itself

Abstract

Aldehydes constitute a main class of organic compounds widely applied in synthesis. As such, catalyst-controlled enantioselective α-functionalization of aldehydes has attracted great interest over the years. In this context, α-branched aldehydes are especially challenging substrates because of reactivity and selectivity issues. Firstly, the transient trisubstituted enamines and enolates resulting upon treatment with an aminocatalyst or a base, respectively, would exhibit attenuated reactivity; secondly, mixtures of

Indexed as

aldehydesasymmetric catalysisdual catalysisorganocatalysisquaternary carbonreaction umpolung

Identifiers

PMID36985666

DOI10.3390/molecules28062694

PMCPMC10056299

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