ArticleMolecules (Basel, Switzerland)2023
Fluorescent Quinolinium Derivative as Novel Mitochondria Probe and Function Modulator by Targeting Mitochondrial RNA.
Bo-Zheng Wang, Ying-Chen Zhou, Yu-Wei Lin, Xiu-Cai Chen, Ze-Yi Yu, Yao-Hao Xu, Jia-Heng Tan, Zhi-Shu Huang, Shuo-Bin Chen
Open access · goldAbstract read
In one paragraphArticle in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 4 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
9 authors at 1 institution in 1 country.
Bo-Zheng WangGuangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Ying-Chen ZhouGuangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Yu-Wei LinGuangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Xiu-Cai ChenGuangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.ORCID 0000-0001-6411-9711 Ze-Yi YuGuangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Yao-Hao XuGuangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Jia-Heng TanGuangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Zhi-Shu HuangGuangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.ORCID 0000-0002-6211-5482 Shuo-Bin ChenGuangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Sun Yat-sen University · CN
Funding
Fundamental Research Funds for the Central Universities 20ykzd16Guangdong Basic and Applied Basic Research Foundation 2019B151502015National Natural Science Foundation of China 81930098, 81872732, 81973184 and 81922063Outstanding Talents of Guangdong Special Plan 2019JC05Y456
6 · The paper itselfAbstract
Mitochondria have a crucial role in regulating energy metabolism and their dysfunction has been linked to tumorigenesis. Cancer diagnosis and intervention have a great interest in the development of new agents that target biomolecules within mitochondria. However, monitoring and modulating mitochondria RNA (mtRNA), an essential component in mitochondria, in cells is challenging due to limited functional research and the absence of targeting agents. In this study, we designed and synthesized a fluorescent quinolinium derivative,
Indexed as
Colorectal NeoplasmsMitochondriaApoptosisCell Line, TumorCell ProliferationFluorescent DyesHumansRNA, MitochondrialFluorescent DyesRNA, Mitochondrialanticancermitochondrial RNAOXPHOS inhibitorRNA fluorescent probe
Identifiers
PMID36985661
PMCPMC10053327
OpenAlexW4327738118
What OpenQuestion holds
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LicenceCC BY
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