ArticleMolecules (Basel, Switzerland)2023
Matrix Effects in GC-MS Profiling of Common Metabolites after Trimethylsilyl Derivatization.
Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Determination of metabolites of the epoxy resin component bisphenol A diglycidyl ether (BADGE) in human urine using gas chromatography-tandem mass spectrometry.Analytical and bioanalytical chemistry · 2026Article
- Polyphenols as Systems Modulators of the Gut-Brain-Liver Axis: A Narrative Review of Neuro-Metabolic and Immunomodulatory Networks.Molecular nutrition & food research · 2026Review
- Development and validation of a GC-MS method for the determination of ethylene glycol and diethylene glycol in pharmaceutical syrups.BMC pharmacology & toxicology · 2026Article
- How Plants May Maintain Protein Homeostasis Under Rising Atmospheric COPlant, cell & environment · 2026Review
- Comparative metabolomic profiling of bovine urine using different sample processing methods by non-targeted GC-MS analysis.Veterinary research communications · 2026Article
- Analyzing Plant Low-Molecular-Weight Polar Metabolites: A GC-MS Approach.Plants (Basel, Switzerland) · 2026Review
- Effect of liner properties on the analysis of lysergic acid diethylamide (LSD) analogs.Journal of forensic sciences · 2026Article
- Assessment of Phytochemical Composition and Antifungal Activity of MicropropagatedPlants (Basel, Switzerland) · 2025Article
- Association of exhaled breath volatile organic compounds with surgical traumatic stress.BMC anesthesiology · 2025Article
- A Novel Sample Preparation Method for GC-MS Analysis of Volatile Organic Compounds in Whole Blood for Veterinary Use.International journal of molecular sciences · 2025Article
- Chemical Characterization in Medical Device Evaluation: Current Practices, Regulatory Requirements, and Future Directions.Annals of biomedical engineering · 2025Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Metabolite profiling using gas chromatography coupled to mass spectrometry (GC-MS) is one of the most frequently applied and standardized methods in research projects using metabolomics to analyze complex samples. However, more than 20 years after the introduction of non-targeted approaches using GC-MS, there are still unsolved challenges to accurate quantification in such investigations. One particularly difficult aspect in this respect is the occurrence of sample-dependent matrix effects. In this project, we used model compound mixtures of different compositions to simplify the study of the complex interactions between common constituents of biological samples in more detail and subjected those to a frequently applied derivatization protocol for GC-MS analysis, namely trimethylsilylation. We found matrix effects as signal suppression and enhancement of carbohydrates and organic acids not to exceed a factor of ~2, while amino acids can be more affected. Our results suggest that the main reason for our observations may be an incomplete transfer of carbohydrate and organic acid derivatives during the injection process and compound interaction at the start of the separation process. The observed effects were reduced at higher target compound concentrations and by using a more suitable injection-liner geometry.
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