Evidence map›Paper›PMID 36985615›Full record

ArticleMolecules (Basel, Switzerland)2023

Virtual Screening of Novel 24-Dehydroxysterol Reductase (

Haozhen Wang, Ziyin Lu, Yang Li, Ting Liu, Linlin Zhao, Tianqi Gao, Xiuli Lu, Bing Gao

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Screening and transcriptomic analysis of anti-Frontiers in microbiology · 2025
    Article
  6. Article
  7. Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Haozhen WangThe School of Life Science, Liaoning University, Chongshanzhong-Lu No. 66, Shenyang 110036, China.ORCID 0000-0003-3522-9481
Ziyin LuThe School of Life Science, Liaoning University, Chongshanzhong-Lu No. 66, Shenyang 110036, China.
Yang LiThe School of Life Science, Liaoning University, Chongshanzhong-Lu No. 66, Shenyang 110036, China.
Ting LiuThe School of Life Science, Liaoning University, Chongshanzhong-Lu No. 66, Shenyang 110036, China.
Linlin ZhaoThe School of Life Science, Liaoning University, Chongshanzhong-Lu No. 66, Shenyang 110036, China.
Tianqi GaoThe School of Life Science, Liaoning University, Chongshanzhong-Lu No. 66, Shenyang 110036, China.
Xiuli LuThe School of Life Science, Liaoning University, Chongshanzhong-Lu No. 66, Shenyang 110036, China.
Bing GaoDepartment of Cell Biology and Genetics, Shenyang Medical College, Shenyang 110034, China.
Liaoning University · CNShenyang Medical College · CN

Funding

National Natural Science Foundation of China No. 31271494 and No. 82070722
6 · The paper itself

Abstract

Hyperlipidemia is a risk factor for the development of fatty liver and cardiovascular diseases such as atherosclerosis and coronary heart disease, and hence, cholesterol-lowering drugs are considered important and effective in preventing cardiovascular diseases. Thus, researchers in the field of new drug development are endeavoring to identify new types of cholesterol-lowering drugs. 3β-hydroxysterol-Δ(24)-reductase (

Indexed as

Cardiovascular DiseasesDiabetes Mellitus, Type 2HypertensionOxidoreductases Acting on CH-CH Group DonorsAnimalsCholesterolDesmosterolIrbesartanMiceNerve Tissue ProteinsOxidoreductasesCholesterolDesmosterolDhcr24 protein, mouseIrbesartanNerve Tissue ProteinsOxidoreductasesOxidoreductases Acting on CH-CH Group Donorscholesterol-lowering drugDHCR24 inhibitorhyperlipidemiairbesartanvirtual screening

Identifiers

PMID36985615
PMCPMC10053925
OpenAlexW4324381479

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.