Evidence map›Paper›PMID 36985593›Full record

ReviewMolecules (Basel, Switzerland)2023

Phage Display-Derived Peptides and Antibodies for Bacterial Infectious Diseases Therapy and Diagnosis.

Hui Zhao, Dan Nie, Yue Hu, Zhou Chen, Zheng Hou, Mingkai Li, Xiaoyan Xue

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Hui ZhaoDepartment of Pharmacology, Air Force Medical University, Xi'an 710032, China.
Dan NieDepartment of Pharmacology, Air Force Medical University, Xi'an 710032, China.
Yue HuDepartment of Pharmacology, Air Force Medical University, Xi'an 710032, China.
Zhou ChenDepartment of Pharmacology, Air Force Medical University, Xi'an 710032, China.
Zheng HouDepartment of Pharmacology, Air Force Medical University, Xi'an 710032, China.ORCID 0000-0002-0358-7869
Mingkai LiDepartment of Pharmacology, Air Force Medical University, Xi'an 710032, China.ORCID 0000-0001-5269-1331
Xiaoyan XueDepartment of Pharmacology, Air Force Medical University, Xi'an 710032, China.
Air Force Medical University · CN

Funding

Air Force Medical University JSTS201805Key Research and Development Program of Shaanxi Province No. 2023-YBSF-629National Natural Science Foundation of China No. 81972359National Natural Science Foundation of China No.82273978
6 · The paper itself

Abstract

The emergence of antibiotic-resistant-bacteria is a serious public health threat, which prompts us to speed up the discovery of novel antibacterial agents. Phage display technology has great potential to screen peptides or antibodies with high binding capacities for a wide range of targets. This property is significant in the rapid search for new antibacterial agents for the control of bacterial resistance. In this paper, we not only summarized the recent progress of phage display for the discovery of novel therapeutic agents, identification of action sites of bacterial target proteins, and rapid detection of different pathogens, but also discussed several problems of this technology that must be solved. Breakthrough in these problems may further promote the development and application of phage display technology in the biomedical field in the future.

Indexed as

Bacterial InfectionsBacteriophagesCommunicable DiseasesAnti-Bacterial AgentsAntibodiesBacterial ProteinsHumansPeptide LibraryPeptidesAnti-Bacterial AgentsAntibodiesBacterial ProteinsPeptide LibraryPeptidesantibacterial adjuvantantibacterial peptideantibodiesanti-virulence strategylibrary constructionmultidrug-resistantphage displayvirulence factor

Identifiers

PMID36985593
PMCPMC10052323
OpenAlexW4324146578

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.