Evidence map›Paper›PMID 36985572›Full record

ArticleMolecules (Basel, Switzerland)2023

Gastrodin and Gastrodigenin Improve Energy Metabolism Disorders and Mitochondrial Dysfunction to Antagonize Vascular Dementia.

Sha Wu, Rong Huang, Ruiqin Zhang, Chuang Xiao, Lueli Wang, Min Luo, Na Song, Jie Zhang, Fang Yang, Xuan Liu and 1 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
9.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Experimental and therapeutic medicine · 2026
    Article
  3. A review of animal models of vascular dementia.Molecular biology reports · 2026
    Review
  4. Article
  5. Article
  6. XIAP Stabilizes DDRGK1 to Promote ER-Phagy and Protects Against Noise-Induced Hearing Loss.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  7. Article
  8. Article
  9. Multi-omics reveals the protective mechanisms ofFrontiers in pharmacology · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. Comparative Phytochemical Analysis ofMolecules (Basel, Switzerland) · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Neuropharmacological effects ofFrontiers in neurology · 2025
    Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Sha WuYunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China.
Rong HuangYunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China.
Ruiqin ZhangShanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Chuang XiaoYunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China.
Lueli WangYunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China.
Min LuoYunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China.
Na SongYunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China.
Jie ZhangYunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China.
Fang YangSchool of Basic Medicine, Kunming Medical University, Kunming 650500, China.
Xuan LiuShanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Weimin YangYunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China.
Kunming Medical University · CNShanghai University of Traditional Chinese Medicine · CN

Funding

National Natural Science Foundation of China 81870037National Natural Science Foundation of China 82060656National Natural Science Foundation of China 82160007National Natural Science Foundation of China 82160013National Natural Science Foundation of China 82260087National Natural Science Foundation of China 82270372Science and Technology Program of Yunnan Province 202001AY070001-196Science and Technology Program of Yunnan Province 202102AA310030Science and Technology Program of Yunnan Province 202105AF150015Wellcome Trust 202202
6 · The paper itself

Abstract

Vascular dementia (VD) is the second most common dementia syndrome worldwide, and effective treatments are lacking.

Indexed as

Dementia, VascularAnimalsBenzyl AlcoholsEnergy MetabolismGlucosidesHippocampusHydrogen PeroxideMitochondriaRats4-hydroxybenzyl alcoholBenzyl AlcoholsgastrodinGlucosidesHydrogen Peroxideenergy metabolismgastrodigeningastrodinmitochondrial functionpharmacological actionvascular dementia

Identifiers

PMID36985572
PMCPMC10059574
OpenAlexW4324146700

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.