Evidence map›Paper›PMID 36985513›Full record

ArticleMolecules (Basel, Switzerland)2023

Structural Insights into the Ligand-LsrK Kinase Binding Mode: A Step Forward in the Discovery of Novel Antimicrobial Agents.

Roberta Listro, Giorgio Milli, Angelica Pellegrini, Chiara Motta, Valeria Cavalloro, Emanuela Martino, Johannes Kirchmair, Giampiero Pietrocola, Daniela Rossi, Pasquale Linciano and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Neurodegeneration: can metabolites fromFrontiers in pharmacology · 2024
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Roberta ListroDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.
Giorgio MilliDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.
Angelica PellegriniDepartment of Molecular Medicine, Biochemistry Unit, University of Pavia, Viale Taramelli 3/b, 27100 Pavia, Italy.
Chiara MottaDepartment of Molecular Medicine, Biochemistry Unit, University of Pavia, Viale Taramelli 3/b, 27100 Pavia, Italy.ORCID 0000-0001-9276-0936
Valeria CavalloroDepartment of Earth and Environmental Sciences, University of Pavia, Via Sant 'Epifanio 14, 27100 Pavia, Italy.
Emanuela MartinoDepartment of Earth and Environmental Sciences, University of Pavia, Via Sant 'Epifanio 14, 27100 Pavia, Italy.ORCID 0000-0001-9591-4996
Johannes KirchmairDivision of Pharmaceutical Chemistry, Department of Pharmaceutical Sciences, University of Vienna, Josef-Holaubek-Platz 2, 2D 303, 1090 Vienna, Austria.ORCID 0000-0003-2667-5877
Giampiero PietrocolaDepartment of Molecular Medicine, Biochemistry Unit, University of Pavia, Viale Taramelli 3/b, 27100 Pavia, Italy.ORCID 0000-0002-7069-8155
Daniela RossiDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.ORCID 0000-0002-2458-3728
Pasquale LincianoDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.ORCID 0000-0003-0382-7479
Simona CollinaDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.ORCID 0000-0002-2954-7558
University of Pavia · ITUniversity of Vienna · AT

Funding

ONE HEALTH BASIC AND TRANSLATIONAL RESEARCH ACTIONS (INF-ACT) PE13_INFACT_PNRR-U.A. 14.01, CUP F13C22001220007
6 · The paper itself

Abstract

LsrK is a bacterial kinase that triggers the quorum sensing, and it represents a druggable target for the identification of new agents for fighting antimicrobial resistance. Herein, we exploited tryptophan fluorescence spectroscopy (TFS) as a suitable technique for the identification of potential LsrK ligands from an in-house library of chemicals comprising synthetic compounds as well as secondary metabolites. Three secondary metabolites (

Indexed as

Anti-Infective AgentsQuorum SensingAnti-Bacterial AgentsBiofilmsLigandsMolecular Docking SimulationAnti-Bacterial AgentsAnti-Infective AgentsLigandsantimicrobial resistancebiofilm inhibitorscircular dichroismdockingLsrKLsrK bindersscreeningtryptophan fluorescence spectroscopy

Identifiers

PMID36985513
PMCPMC10056567
OpenAlexW4324070669

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.