Evidence map›Paper›PMID 36985499›Full record

ArticleMolecules (Basel, Switzerland)2023

Delivery of Active Peptides by Self-Healing, Biocompatible and Supramolecular Hydrogels.

Seyedeh Rojin Shariati Pour, Sara Oddis, Marianna Barbalinardo, Paolo Ravarino, Massimiliano Cavallini, Jessica Fiori, Demetra Giuri, Claudia Tomasini

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Design, optimization, andVeterinary world · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Controlled Lactonization ofGels (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Seyedeh Rojin Shariati PourDepartment of Chemistry Giacomo Ciamician, University of Bologna, Via Selmi 2, 40126 Bologna, Italy.
Sara OddisDepartment of Chemistry Giacomo Ciamician, University of Bologna, Via Selmi 2, 40126 Bologna, Italy.
Marianna BarbalinardoNational Research Council, Institute for the Study of Nanostructured Materials (CNR-ISMN), Via P. Gobetti 101, 40129 Bologna, Italy.ORCID 0000-0002-2143-2860
Paolo RavarinoDepartment of Chemistry Giacomo Ciamician, University of Bologna, Via Selmi 2, 40126 Bologna, Italy.
Massimiliano CavalliniNational Research Council, Institute for the Study of Nanostructured Materials (CNR-ISMN), Via P. Gobetti 101, 40129 Bologna, Italy.
Jessica FioriDepartment of Chemistry Giacomo Ciamician, University of Bologna, Via Selmi 2, 40126 Bologna, Italy.
Demetra GiuriDepartment of Chemistry Giacomo Ciamician, University of Bologna, Via Selmi 2, 40126 Bologna, Italy.ORCID 0000-0001-5923-7836
Claudia TomasiniDepartment of Chemistry Giacomo Ciamician, University of Bologna, Via Selmi 2, 40126 Bologna, Italy.ORCID 0000-0002-6310-2704

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Supramolecular and biocompatible hydrogels with a tunable pH ranging from 5.5 to 7.6 lead to a wide variety of formulations useful for many different topical applications compatible with the skin pH. An in vitro viability/cytotoxicity test of the gel components demonstrated that they are non-toxic, as the cells continue to proliferate after 48 h. An analysis of the mechanical properties demonstrates that the hydrogels have moderate strength and an excellent linear viscoelastic range with the absence of a proper breaking point, confirmed with thixotropy experiments. Two cosmetic active peptides (Trifluoroacetyl tripeptide-2 and Palmitoyl tripeptide-5) were successfully added to the hydrogels and their transdermal permeation was analysed with Franz diffusion cells. The liquid chromatography-mass spectrometry (HPLC-MS) analyses of the withdrawn samples from the receiving solutions showed that Trifluoroacetyl tripeptide-2 permeated in a considerable amount while almost no transdermal permeation of Palmitoyl tripeptide-5 was observed.

Indexed as

HydrogelsPeptidesAdministration, CutaneousBiocompatible MaterialsDrug CompoundingBiocompatible MaterialsHydrogelsPeptidesFranz diffusion cellshydrogelslow-molecular-weight gelatorspeptidesself-assembly

Identifiers

PMID36985499
PMCPMC10057174

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.