Evidence map›Paper›PMID 36985402›Full record

ArticleMolecules (Basel, Switzerland)2023

Exploring the Potential of Phytocompounds for Targeting Epigenetic Mechanisms in Rheumatoid Arthritis: An In Silico Study Using Similarity Indexing.

Sanjay H Deshpande, Zabin K Bagewadi, T M Yunus Khan, Mater H Mahnashi, Ibrahim Ahmed Shaikh, Sultan Alshehery, Aejaz A Khan, Vishal S Patil, Subarna Roy

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Sanjay H DeshpandeDepartment of Biotechnology, KLE Technological University, Hubballi 580031, India.ORCID 0000-0001-6951-6767
Zabin K BagewadiDepartment of Biotechnology, KLE Technological University, Hubballi 580031, India.ORCID 0000-0002-6650-7045
T M Yunus KhanDepartment of Mechanical Engineering, College of Engineering, King Khalid University, Abha 61421, Saudi Arabia.ORCID 0000-0002-9242-7591
Mater H MahnashiDepartment of Pharmaceutical Chemistry, College of Pharmacy, Najran University, Najran 66462, Saudi Arabia.ORCID 0000-0002-4837-3653
Ibrahim Ahmed ShaikhDepartment of Pharmacology, College of Pharmacy, Najran University, Najran 66462, Saudi Arabia.ORCID 0000-0001-9812-2628
Sultan AlsheheryDepartment of Mechanical Engineering, College of Engineering, King Khalid University, Abha 61421, Saudi Arabia.ORCID 0000-0002-3655-7594
Aejaz A KhanDepartment of General Science, Ibn Sina National College for Medical Studies, Jeddah 22421, Saudi Arabia.ORCID 0000-0002-5731-7522
Vishal S PatilICMR-National Institute of Traditional Medicine, Belagavi 590010, India.ORCID 0000-0002-1219-1962
Subarna RoyICMR-National Institute of Traditional Medicine, Belagavi 590010, India.ORCID 0000-0002-6594-8615
King Khalid University · SAKLE Technological University · INNajran University · SAIbn Sina National College for Medical Studies · SA

Funding

Najran University NU/RG/MRC/12/3
6 · The paper itself

Abstract

Finding structurally similar compounds in compound databases is highly efficient and is widely used in present-day drug discovery methodology. The most-trusted and -followed similarity indexing method is Tanimoto similarity indexing. Epigenetic proteins like histone deacetylases (HDACs) inhibitors are traditionally used to target cancer, but have only been investigated very recently for their possible effectiveness against rheumatoid arthritis (RA). The synthetic drugs that have been identified and used for the inhibition of HDACs include SAHA, which is being used to inhibit the activity of HDACs of different classes. SAHA was chosen as a compound of high importance as it is reported to inhibit the activity of many HDAC types. Similarity searching using the UNPD database as a reference identified aglaithioduline from the

Indexed as

Arthritis, RheumatoidHistone Deacetylase InhibitorsAmidesEpigenesis, GeneticHistone DeacetylasesHumansMolecular Docking SimulationMolecular Dynamics SimulationRepressor ProteinsSulfidesaglaithiodulineAmidesHDAC8 protein, humanHistone Deacetylase InhibitorsHistone DeacetylasesRepressor ProteinsSulfidesAglaia edulisAglaia leptanthamolecular dockingmolecular dynamicsrheumatoid arthritissimilarity indexingtraditional medicine

Identifiers

PMID36985402
PMCPMC10051859
OpenAlexW4323567922

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.