Evidence map›Paper›PMID 36985343›Full record

ArticleMicroorganisms2023

Oral Supplementation with Hydroxytyrosol Synthesized Using Genetically Modified

Yannis V Simos, Stelios Zerikiotis, Panagiotis Lekkas, Antrea-Maria Athinodorou, Christianna Zachariou, Christina Tzima, Alexandros Assariotakis, Dimitrios Peschos, Konstantinos Tsamis, Maria Halabalaki and 8 more

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microorganisms, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Molecules (Basel, Switzerland) · 2025
    Review
  2. Evaluating the Chemical Composition and Antitumor Activity ofInternational journal of molecular sciences · 2025
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 1 country.

Yannis V SimosLaboratory of Physiology, Department of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece.ORCID 0000-0003-1764-8906
Stelios ZerikiotisLaboratory of Physiology, Department of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece.
Panagiotis LekkasLaboratory of Physiology, Department of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece.ORCID 0000-0002-2285-0060
Antrea-Maria AthinodorouLaboratory of Physiology, Department of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece.ORCID 0000-0002-5060-4588
Christianna ZachariouLaboratory of Physiology, Department of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece.
Christina TzimaLaboratory of Physiology, Department of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece.
Alexandros AssariotakisLaboratory of Agronomy, Department of Crop Science, Agricultural University of Athens, 11855 Athens, Greece.
Dimitrios PeschosLaboratory of Physiology, Department of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece.
Konstantinos TsamisLaboratory of Physiology, Department of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece.ORCID 0000-0002-7032-1630
Maria HalabalakiDepartment of Pharmacy, Division of Pharmacognosy and Natural Products Chemistry, National and Kapodistrian University of Athens, Panepistimioupoli Zografou, 11527 Athens, Greece.ORCID 0000-0001-5620-0165
Filippos VerveridisLaboratory of Biological & Biotechnological Applications, Department of Agriculture, School of Agricultural Sciences, Hellenic Mediterranean University, Estavromenos, 71410 Heraklion, Greece.ORCID 0000-0002-3104-6103
Emmanouil A TrantasLaboratory of Biological & Biotechnological Applications, Department of Agriculture, School of Agricultural Sciences, Hellenic Mediterranean University, Estavromenos, 71410 Heraklion, Greece.ORCID 0000-0001-7536-101X
Garyfalia EconomouLaboratory of Agronomy, Department of Crop Science, Agricultural University of Athens, 11855 Athens, Greece.
Petros TarantilisLaboratory of Chemistry, Department of Food Science & Human Nutrition, School of Food and Nutritional Sciences, Agricultural University of Athens, 11855 Athens, Greece.ORCID 0000-0002-5853-4780
Argyro VontzalidouSymbeeosis S.A., 19002 Athens, Greece.
Irini VallianatouSymbeeosis S.A., 19002 Athens, Greece.ORCID 0000-0002-0664-0207
Charalambos AngelidisDepartment of Biology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece.
Patra VezyrakiLaboratory of Physiology, Department of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece.
University of Ioannina · GRAgricultural University of Athens · GRHellenic Mediterranean University · GRNational and Kapodistrian University of Athens · GR

Funding

European Regional Development Fund of the European Union and Greek national funds through the Operational Program Competitiveness, Entrepreneurship and Innovation, under the call RESEARCH-CREATE-INNOVATE T1EDK-04267
6 · The paper itself

Abstract

Several natural compounds have been explored as immune-boosting, antioxidant and anti-inflammatory dietary supplements. Amongst them, hydroxytyrosol, a natural antioxidant found in olive products, and endemic medicinal plants have attracted the scientific community's and industry's interest. We investigated the safety and biological activity of a standardised supplement containing 10 mg of hydroxytyrosol synthesized using genetically modified

Indexed as

antioxidantsdietary supplementsessential oilshydroxytyrosoloxidised low-density lipoprotein

Identifiers

PMID36985343
PMCPMC10051181
OpenAlexW4327715635

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read73
identifiers read1
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.