Evidence map›Paper›PMID 36985128›Full record

ArticleMicroorganisms2023

Evaluation of the Toxic Activity of the Graphene Oxide in the Ex Vivo Model of Human PBMC Infection with

Alessandro Salustri, Flavio De Maio, Valentina Palmieri, Giulia Santarelli, Ivana Palucci, Delia Mercedes Bianco, Federica Marchionni, Silvia Bellesi, Gabriele Ciasca, Giordano Perini and 5 more

Open access · goldAbstract read
In one paragraph

Article in Microorganisms, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
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  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Alessandro SalustriDipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie-Sezione di Microbiologia, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Flavio De MaioDipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario "A. Gemelli", IRCCS, 00168 Rome, Italy.ORCID 0000-0002-4744-9820
Valentina PalmieriIstituto dei Sistemi Complessi, CNR, 00168 Rome, Italy.
Giulia SantarelliDipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie-Sezione di Microbiologia, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.ORCID 0000-0001-9340-3842
Ivana PalucciDipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie-Sezione di Microbiologia, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.ORCID 0000-0003-2106-1761
Delia Mercedes BiancoDipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie-Sezione di Microbiologia, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.ORCID 0000-0001-6199-6372
Federica MarchionniDipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario "A. Gemelli", IRCCS, 00168 Rome, Italy.
Silvia BellesiDipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario "A. Gemelli", IRCCS, 00168 Rome, Italy.
Gabriele CiascaFondazione Policlinico Universitario "A. Gemelli", IRCSS, 00168 Rome, Italy.
Giordano PeriniFondazione Policlinico Universitario "A. Gemelli", IRCSS, 00168 Rome, Italy.ORCID 0000-0001-9452-8479
Maurizio SanguinettiDipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie-Sezione di Microbiologia, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.ORCID 0000-0002-9780-7059
Michela SaliDipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie-Sezione di Microbiologia, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Massimiliano PapiFondazione Policlinico Universitario "A. Gemelli", IRCSS, 00168 Rome, Italy.ORCID 0000-0002-0029-1309
Marco De SpiritoFondazione Policlinico Universitario "A. Gemelli", IRCSS, 00168 Rome, Italy.
Giovanni DeloguDipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie-Sezione di Microbiologia, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Università Cattolica del Sacro Cuore · ITAgostino Gemelli University Polyclinic · IT

Funding

Catholic University of the Sacred Heart Linea D3.2 2017 and Linea D1
6 · The paper itself

Abstract

Graphene Oxide has been proposed as a potential adjuvant to develop improved anti-TB treatment, thanks to its activity in entrapping mycobacteria in the extracellular compartment limiting their entry in macrophages. Indeed, when administered together with linezolid, Graphene Oxide significantly enhanced bacterial killing due to the increased production of Reactive Oxygen Species. In this work, we evaluated Graphene Oxide toxicity and its anti-mycobacterial activity on human peripheral blood mononuclear cells. Our data show that Graphene Oxide, different to what is observed in macrophages, does not support the clearance of

Indexed as

graphene oxidemycobacterium tuberculosis infectionPBMCs

Identifiers

PMID36985128
PMCPMC10059016
OpenAlexW4321496363

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.