Evidence map›Paper›PMID 36984841›Full record

ArticleMetabolites2023

Metabolome × Microbiome Changes Associated with a Diet-Induced Reduction in Hepatic Fat among Adolescent Boys.

Catherine C Cohen, Helaina Huneault, Carolyn J Accardi, Dean P Jones, Ken Liu, Kristal M Maner-Smith, Ming Song, Jean A Welsh, Patricia A Ugalde-Nicalo, Jeffrey B Schwimmer and 1 more

Abstract read
In one paragraph

Article in Metabolites, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Catherine C CohenDepartment of Pediatrics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0002-8402-0118
Helaina HuneaultNutrition & Health Sciences Doctoral Program, Laney Graduate School, Emory University, Atlanta, GA 30322, USA.
Carolyn J AccardiDepartment of Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA.
Dean P JonesDepartment of Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA.
Ken LiuDepartment of Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA.
Kristal M Maner-SmithEmory Integrated Lipidomics Core, School of Medicine, Emory University, Atlanta, GA 30322, USA.ORCID 0000-0002-2274-4284
Ming SongDepartment of Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA.
Jean A WelshNutrition & Health Sciences Doctoral Program, Laney Graduate School, Emory University, Atlanta, GA 30322, USA.
Patricia A Ugalde-NicaloDepartment of Gastroenterology, Rady Children's Hospital San Diego, San Diego, CA 92123, USA.
Jeffrey B SchwimmerDepartment of Gastroenterology, Rady Children's Hospital San Diego, San Diego, CA 92123, USA.
Miriam B VosNutrition & Health Sciences Doctoral Program, Laney Graduate School, Emory University, Atlanta, GA 30322, USA.

Funding

Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
WKU Lead Faculty AwardP20GM103436 · NIGMS · UNIVERSITY OF LOUISVILLE · PI ERIC C ROUCHKA · 2012 to 2026
$60.1M
Role of oxidized linoleic acid metabolites in the pathogenesis of alcoholic liver diseaseP20GM113226 · NIGMS · UNIVERSITY OF LOUISVILLE · PI HOOD, JOSHUA L. · 2016 to 2025
$24.1M
Pilot Project ProgramP30ES019776 · NIEHS · EMORY UNIVERSITY · PI William Michael Caudle · 2013 to 2026
$22.6M
NIDDK National Research Service Award (NRSA) T32 Diversity Administrative SupplementT32DK007658 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Kristen Elizabeth Boyle, Ihuoma U Eneli · 1991 to 2026
$6.0M
PILOT PROJECT PROGRAMP30GM106396 · NIGMS · UNIVERSITY OF LOUISVILLE · PI MILLER, DONALD M. · 2013 to 2017
$5.4M
Sibling Assessment in Prevention of Pediatric NAFLD in Hispanic ChildrenR01NR019083 · NINR · EMORY UNIVERSITY · PI WELSH, JEAN A. · 2021 to 2025
$3.3M
Biomarker Discovery for Nonalcoholic Fatty Liver Disease in ChildrenR01DK125701 · NIDDK · EMORY UNIVERSITY · PI VOS, MIRIAM B. · 2020 to 2022
$1.0M
Lifecourse dietary exposures and offspring hepatic fat in early childhood: a nutrigenomic approachF32DK131757 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI COHEN, CATHERINE CIOFFI · 2022 to 2023
$104k
NCATS NIH HHS UL1 TR001442NCATS NIH HHS UL1TR001442NCATS NIH HHS UL1 TR002378NIDDK NIH HHS F32 DK131757NIDDK NIH HHS F32DK131757NIDDK NIH HHS R01 DK125701NIDDK NIH HHS R01DK125701NIDDK NIH HHS T32 DK007658NIDDK NIH HHS T32DK07658NIEHS NIH HHS P30 ES019776NIEHS NIH HHS P30ES019776NIGMS NIH HHS P20 GM103436NIGMS NIH HHS P20GM103436NIGMS NIH HHS P20GM106396NIGMS NIH HHS P20 GM113226NIGMS NIH HHS P20GM113226NIGMS NIH HHS P30 GM106396NINR NIH HHS R01 NR019083NINR NIH HHS R01NR019083
6 · The paper itself

Abstract

Dietary sugar reduction is one therapeutic strategy for improving nonalcoholic fatty liver disease (NAFLD), and the underlying mechanisms for this effect warrant further investigation. Here, we employed metabolomics and metagenomics to examine systemic biological adaptations associated with dietary sugar restriction and (subsequent) hepatic fat reductions in youth with NAFLD. Data/samples were from a randomized controlled trial in adolescent boys (11-16 years, mean ± SD: 13.0 ± 1.9 years) with biopsy-proven NAFLD who were either provided a low free-sugar diet (LFSD) (

Indexed as

fatty liver diseaseliquid chromatography-mass spectrometryobesitypediatricsugar

Identifiers

PMID36984841
PMCPMC10053986

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.