Evidence map›Paper›PMID 36984765›Full record

ArticleMetabolites2023

Metabolic Features of Increased Gut Permeability, Inflammation, and Altered Energy Metabolism Distinguish Agricultural Workers at Risk for Mesoamerican Nephropathy.

Nathan H Raines, Dominick A Leone, Cristina O'Callaghan-Gordo, Oriana Ramirez-Rubio, Juan José Amador, Damaris Lopez Pilarte, Iris S Delgado, Jessica H Leibler, Nieves Embade, Rubén Gil-Redondo and 7 more

Open access · goldAbstract read
In one paragraph

Article in Metabolites, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 11 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Heat-induced kidney disease: Understanding the impact.Journal of internal medicine · 2025
    Review
  8. Article
  9. The Promise of Metabolomics and Exposomics in CKDu.Kidney international reports · 2024
    Article
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 2 countries.

Nathan H RainesDivision of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.ORCID 0000-0003-3297-9447
Dominick A LeoneDepartment of Epidemiology, Boston University School of Public Health, Boston, MA 02118, USA.ORCID 0000-0002-6401-2292
Cristina O'Callaghan-GordoFaculty of Health Sciences, Universitat Oberta de Catalunya, 08018 Barcelona, Spain.ORCID 0000-0002-4229-2991
Oriana Ramirez-RubioDepartment of Epidemiology, Boston University School of Public Health, Boston, MA 02118, USA.
Juan José AmadorDepartment of Epidemiology, Boston University School of Public Health, Boston, MA 02118, USA.
Damaris Lopez PilarteDepartment of Epidemiology, Boston University School of Public Health, Boston, MA 02118, USA.
Iris S DelgadoDepartment of Epidemiology, Boston University School of Public Health, Boston, MA 02118, USA.
Jessica H LeiblerDepartment of Environmental Health, Boston University School of Public Health, Boston, MA 02118, USA.ORCID 0000-0002-0605-0928
Nieves EmbadePrecision Medicine and Metabolism Laboratory, CIC bioGUNE, Basque Research and Technology Alliance (BRTA), 48160 Derio, Spain.ORCID 0000-0001-9878-3290
Rubén Gil-RedondoPrecision Medicine and Metabolism Laboratory, CIC bioGUNE, Basque Research and Technology Alliance (BRTA), 48160 Derio, Spain.ORCID 0000-0002-3541-9085
Chiara BruzzonePrecision Medicine and Metabolism Laboratory, CIC bioGUNE, Basque Research and Technology Alliance (BRTA), 48160 Derio, Spain.ORCID 0000-0003-4252-8180
Maider BizkarguenagaPrecision Medicine and Metabolism Laboratory, CIC bioGUNE, Basque Research and Technology Alliance (BRTA), 48160 Derio, Spain.
Madeleine K ScammellDepartment of Epidemiology, Boston University School of Public Health, Boston, MA 02118, USA.ORCID 0000-0003-3836-083X
Samir M ParikhDivision of Nephrology, Department of Medicine, University of Texas Southwestern Medical School, Dallas, TX 75390, USA.
Oscar MilletPrecision Medicine and Metabolism Laboratory, CIC bioGUNE, Basque Research and Technology Alliance (BRTA), 48160 Derio, Spain.ORCID 0000-0001-8748-4105
Daniel R BrooksDepartment of Epidemiology, Boston University School of Public Health, Boston, MA 02118, USA.
David J FriedmanDivision of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Boston University · USCIC bioGUNE · ESBeth Israel Deaconess Medical Center · USInstituto de Salud Carlos III · ESThe University of Texas Southwestern Medical Center · USUniversitat Oberta de Catalunya · ES

Funding

The Aging Kidney: Chronic Injury, Impaired Functions and Clinical OutcomesR01AG027002 · NIA · TUFTS MEDICAL CENTER · PI PARIKH, SAMIR M, SARNAK, MARK J · 2005 to 2022
$7.3M
Tie2-driven vascular control in critical illnessR35HL139424 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI PARIKH, SAMIR M · 2018 to 2024
$6.4M
Mitochondrial Biogenesis in Kidney DiseaseR01DK095072 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Samir M Parikh · 2012 to 2026
$5.3M
Role of Genetic Susceptibility in the Central American Kidney Disease EpidemicR01DK116021 · NIDDK · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BROOKS, DANIEL R, FRIEDMAN, DAVID J · 2018 to 2022
$3.7M
Doris Duke Charitable Foundation 2021082Doris Duke Charitable Foundation 202182NHLBI NIH HHS R35 HL139424NIA NIH HHS R01 AG027002NIDDK NIH HHS R01 DK095072NIDDK NIH HHS R01 DK116021NIDDK NIH HHS R01DK116021
6 · The paper itself

Abstract

Mesoamerican nephropathy (MeN) is a form of chronic kidney disease found predominantly in young men in Mesoamerica. Strenuous agricultural labor is a consistent risk factor for MeN, but the pathophysiologic mechanism leading to disease is poorly understood. We compared the urine metabolome among men in Nicaragua engaged in sugarcane harvest and seed cutting (

Indexed as

agriculturechronic kidney disease of nontraditional cause (CKDnt)chronic kidney disease of unknown etiology (CKDu)hippuratekynurenatemanual laborMesoamerican nephropathy (MeN)nicotinamide adenine dinucleotide (NAD+)tryptophan

Identifiers

PMID36984765
PMCPMC10058628
OpenAlexW4321495973

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.