Evidence map›Paper›PMID 36984752›Full record

ArticleMembranes2023

Structural and Functional Characterization of the Newly Designed Antimicrobial Peptide Crabrolin21.

Francesca Cantini, Paola Giannì, Sara Bobone, Cassandra Troiano, Hugo van Ingen, Renato Massoud, Nicoletta Perini, Luciana Migliore, Philippe Savarin, Charles Sanders and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Membranes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Francesca CantiniMagnetic Resonance Center (CERM), University of Florence, Sesto Fiorentino, 50019 Firenze, Italy.ORCID 0000-0003-0526-6732
Paola GiannìDepartment of Chemical Sciences and Technology, University of Rome Tor Vergata, 00133 Rome, Italy.
Sara BoboneDepartment of Chemical Sciences and Technology, University of Rome Tor Vergata, 00133 Rome, Italy.
Cassandra TroianoDepartment of Chemical Sciences and Technology, University of Rome Tor Vergata, 00133 Rome, Italy.
Hugo van IngenNMR Spectroscopy, Bijvoet Center for Biomolecular Research, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands.ORCID 0000-0002-0808-3811
Renato MassoudDepartment of Experimental Medicine, University of Rome Tor Vergata, Viale della Ricerca Scientifica, 00133 Rome, Italy.
Nicoletta PeriniDepartment of Biology, University of Rome Tor Vergata, 00133 Rome, Italy.
Luciana MiglioreDepartment of Biology, University of Rome Tor Vergata, 00133 Rome, Italy.ORCID 0000-0003-3554-3841
Philippe SavarinChemistry Structures Properties of Biomaterials and Therapeutic Agents Laboratory (CSPBAT), Nanomédecine Biomarqueurs Détection Team (NBD), Sorbonne Paris Nord University, The National Center for Scientific Research (CNRS), UMR 7244, 74 Rue Marcel Cachin, CEDEX, 93017 Bobigny, France.ORCID 0000-0003-1451-2376
Charles SandersDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Lorenzo StellaDepartment of Chemical Sciences and Technology, University of Rome Tor Vergata, 00133 Rome, Italy.ORCID 0000-0002-5489-7381
Marco SetteDepartment of Chemical Sciences and Technology, University of Rome Tor Vergata, 00133 Rome, Italy.ORCID 0000-0002-8604-499X

Funding

iNEXT-Discovery in Horizon 2020 871037Italian Ministry of University and Research PRIN project 2020833Y75Regione Lazio Contributo premiale per i ricercatori 2022', DE G05411
6 · The paper itself

Abstract

(1) Background: antimicrobial resistance is becoming a dramatic problem for public health, and the design of new antimicrobial agents is an active research area. (2) Methods: based on our previous work, we designed an improved version of the crabrolin peptide and characterized its functional and structural properties with a wide range of techniques. (3) Results: the newly designed peptide, crabrolin21, is much more active than the previous ones and shows specific selectivity towards bacterial cells. (4) Conclusions: crabrolin21 shows interesting properties and deserves further studies.

Indexed as

antimicrobial resistanceCD spectroscopymembrane specificityNMR spectroscopy

Identifiers

PMID36984752
PMCPMC10053045

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.