Evidence map›Paper›PMID 36984222›Full record

ArticleMaterials (Basel, Switzerland)2023

Influence of Trabecular Geometry on Scaffold Mechanical Behavior and MG-63 Cell Viability.

Maria Laura Gatto, Giorgia Cerqueni, Michele Furlani, Nicole Riberti, Emanuele Tognoli, Lucia Denti, Francesco Leonardi, Alessandra Giuliani, Monica Mattioli-Belmonte, Paolo Mengucci

Abstract read
In one paragraph

Article in Materials (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Maria Laura GattoDepartment DIISM, Università Politecnica Delle Marche, Via Brecce Bianche 12, 60131 Ancona, Italy.
Giorgia CerqueniDepartment DISCLIMO & UdR INSTM, Università Politecnica Delle Marche, Via Tronto 10/a, 60126 Ancona, Italy.ORCID 0000-0001-7390-7154
Michele FurlaniDepartment DISCO, Università Politecnica Delle Marche, Via Brecce Bianche 12, 60131 Ancona, Italy.ORCID 0000-0002-9261-2682
Nicole RibertiNeurosciences Imaging and Clinical Sciences Department, University of Chieti-Pescara, 66100 Chieti, Italy.
Emanuele TognoliDepartment of Engineering "Enzo Ferrari", Università di Modena e Reggio Emilia, Via Vivarelli 10, 41125 Modena, Italy.ORCID 0000-0002-7623-5311
Lucia DentiDepartment of Engineering "Enzo Ferrari", Università di Modena e Reggio Emilia, Via Vivarelli 10, 41125 Modena, Italy.ORCID 0000-0002-4118-8375
Francesco LeonardiPuntoZero 3D S.r.l., Via Larga 19, 20122 Milano, Italy.
Alessandra GiulianiDepartment DISCO, Università Politecnica Delle Marche, Via Brecce Bianche 12, 60131 Ancona, Italy.ORCID 0000-0003-4177-7441
Monica Mattioli-BelmonteDepartment DISCLIMO & UdR INSTM, Università Politecnica Delle Marche, Via Tronto 10/a, 60126 Ancona, Italy.ORCID 0000-0002-2087-2776
Paolo MengucciDepartment SIMAU & UdR INSTM, Università Politecnica Delle Marche, Via Brecce Bianche 12, 60131 Ancona, Italy.ORCID 0000-0001-9049-8524

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In a scaffold-based approach for bone tissue regeneration, the control over morphometry allows for balancing scaffold biomechanical performances. In this experimental work, trabecular geometry was obtained by a generative design process, and scaffolds were manufactured by vat photopolymerization with 60% (P60), 70% (P70) and 80% (P80) total porosity. The mechanical and biological performances of the produced scaffolds were investigated, and the results were correlated with morphometric parameters, aiming to investigate the influence of trabecular geometry on the elastic modulus, the ultimate compressive strength of scaffolds and MG-63 human osteosarcoma cell viability. The results showed that P60 trabecular geometry allows for matching the mechanical requirements of human mandibular trabecular bone. From the statistical analysis, a general trend can be inferred, suggesting strut thickness, the degree of anisotropy, connectivity density and specific surface as the main morphometric parameters influencing the biomechanical behavior of trabecular scaffolds, in the perspective of tissue engineering applications.

Indexed as

biomechanical performancesgenerative designmorphometric parameterstissue engineeringtrabecular geometryvat photopolymerization

Identifiers

PMID36984222
PMCPMC10056383

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.