Evidence map›Paper›PMID 36983894›Full record

ArticleLife (Basel, Switzerland)2023

Protective and Therapeutic Capacities of Lactic Acid Bacteria Postmetabolites against Koi Herpesvirus Infection In Vitro.

Neli Vilhelmova-Ilieva, Svetla Danova, Zdravka Petrova, Lili Dobreva, Georgi Atanasov, Kapka Mancheva, Lora Simeonova

Open access · goldAbstract read
In one paragraph

Article in Life (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. The therapeutic potential ofFrontiers in microbiology · 2026
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Neli Vilhelmova-IlievaThe Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 26 Georgi Bonchev Str., 1113 Sofia, Bulgaria.ORCID 0000-0003-4772-4471
Svetla DanovaThe Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 26 Georgi Bonchev Str., 1113 Sofia, Bulgaria.
Zdravka PetrovaThe Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 26 Georgi Bonchev Str., 1113 Sofia, Bulgaria.
Lili DobrevaThe Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 26 Georgi Bonchev Str., 1113 Sofia, Bulgaria.
Georgi AtanasovInstitute of Biodiversity and Ecosystem Research, Bulgarian Academy of Sciences, 25 Georgi Bonchev Str., 1113 Sofia, Bulgaria.
Kapka ManchevaInstitute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, 23 Georgi Bonchev Str., 1113 Sofia, Bulgaria.
Lora SimeonovaThe Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 26 Georgi Bonchev Str., 1113 Sofia, Bulgaria.
Bulgarian Academy of Sciences · BG

Funding

Bulgarian Science Fund КП-06-Н 36/4
6 · The paper itself

Abstract

backgroundThe accumulation of data on beneficial biological effects of probiotics and their metabolic products favors their potential use in the prevention and treatment of various malaises.

methodsNine postmetabolites from Lactic acid bacteria (LAB) of human or dairy origin and their antiviral activity were studied using the cytopathic effect inhibition test. The virucidal capacity, their influence on the adsorption stage of Koi herpes virus (KHV) and their preventive role against subsequent viral challenge on intact Common carp brain (CCB) cells were also determined by titration assay. Residual viral infectivity in postmetabolites-treated samples was compared to mock-treated controls and Δlgs were calculated.

resultsWhen administered during KHV replication, the microbial products isolated from

conclusionsOur results open new horizons and promote LAB and their postbiotic products to be used in the prophylaxis and therapy of viral infections.

Indexed as

antiviral activitycell protectionKoi herpes virusLABpostmetabolitesprobiotics

Identifiers

PMID36983894
PMCPMC10054248
OpenAlexW4323668409

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.