ArticleLife (Basel, Switzerland)2023
Myofascial Pain Syndrome: A Nociceptive Condition Comorbid with Neuropathic or Nociplastic Pain.
Article in Life (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Treating myofascial pain with dry needling: a systematic review for the best evidence-based practices in low back pain.Arquivos de neuro-psiquiatria · 2023Pooled it
- Effect of photobiomodulation on trapezius myofascial pain: a randomized, sham-controlled, double-blind clinical trial.Lasers in medical science · 2026Trial
- Trial
- Pelvic floor examination in vulvodynia: VAMP protocol validation in correlation with central sensitization.Women's health (London, England)Trial
- Adapting Tension-Type Headache to the International Association for the Study of Pain (IASP) Taxonomy: A Conceptual Proposal.Biomedicines · 2026Review
- Targeted cryostimulation of myofascial trigger points modulates exercise-induced physiological tremor in adolescent swimmers: a randomized counterbalanced crossover trial.BMC sports science, medicine & rehabilitation · 2026Article
- Prevalence and Predictive Factors of Active Myofascial Trigger Points Among Office Workers Using to Visual Display Terminals: A Cross-Sectional Study.Archives of rehabilitation research and clinical translation · 2026Article
- Diagnostic re-evaluation of non-odontogenic orofacial pain after treatment failure: a retrospective case series.Journal of oral & facial pain and headache · 2026Article
- Effects of extracorporeal shockwave therapy on pain and pelvic floor function in women with pelvic floor myofascial pain: a retrospective cohort analysis.BMC women's health · 2026Article
- The Role of Muscle Trigger Points in Chronic Whiplash-Associated Disorders with Neuropathic Pain Components: An Exploratory Cross-Sectional Study.Journal of clinical medicine · 2026Article
- Is Pain Intensity Related to Psychosocial Factors in Chronic Non-Nociceptive Orofacial Pain Patients?Journal of oral rehabilitation · 2026Article
- Deciphering the pharmacological paradox: mechanism mismatch and stratification inadequacies in herbal-NSAID combination therapy.International journal of surgery (London, England) · 2026Article
- Elasticity mapping of gastrocnemius fascia and myotendinous junction of the medial gastrocnemius during passive ankle and knee dorsiflexion.Frontiers in sports and active living · 2026Article
- Metabolomic Insights into Reprogrammed Caffeine Metabolism in the Hippocampus of Myofascial Pain Syndrome Rats.Journal of pain research · 2026Article
- Referred Pain Manifestation and Its Impact on Patients With Temporomandibular Disorder.Oral diseases · 2025Article
- The pathophysiologic mechanisms of spinal manipulative therapy in the management of chronic musculoskeletal pain.The Journal of the Canadian Chiropractic Association · 2025Article
- Neuropathic pain and central sensitization in patients with rheumatoid arthritis attending a tertiary hospital.Advances in rheumatology (London, England) · 2025Article
- Evaluation of the presence of neuropathic pain and/or central sensitization in patients with radiographic axial spondyloarthritis followed at a tertiary hospital.Advances in rheumatology (London, England) · 2025Observational
- Delayed-Onset Postsurgical Myofascial Pain Following Axillary Artery Cannulation: A Case Report.Cureus · 2025Article
- Prevalence of Myofascial Trigger Points in Patients with Radiating and Non-Radiating Low Back Pain: A Systematic Review.Biomedicines · 2025Review
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myofascial pain syndrome is featured by the presence of myofascial trigger points (TrPs). Whether TrPs are primary or secondary phenomena or if they relate to central or peripheral nervous system disorders is controversial. Referred pain, a cardinal sign of TrPs, is a central phenomenon driven by peripheral input. In 2021, the International Association for the Study of Pain (IASP) proposed a clinical criteria and grading system for classifying patients with pain on nociceptive, neuropathic, or nociplastic phenotypes. Myofascial TrP pain has been traditionally categorized as a nociceptive phenotype; however, increasing evidence supports that this condition could be present in patients with predominantly nociplastic pain, particularly when it is associated with an underlying medical condition. The clinical response of some therapeutic approaches for managing TrPs remains unclear. Accordingly, the ability to classify myofascial TrP pain into one of these phenotypes would likely be critical for producing more successful clinical treatment outcomes by a precision medicine approach. This consensus paper presents evidence supporting the possibility of subgrouping individuals with myofascial TrP pain into nociceptive, nociplastic, or mixed-type phenotype. It is concluded that myofascial pain caused by TrPs is primarily a nociceptive pain condition, is unlikely to be classified as neuropathic or nociplastic, but can be present in patients with predominantly neuropathic or nociplastic pain. In the latter cases, management of the predominant central pain problem should be a major treatment goal, but the peripheral drive from TrPs should not be ignored, since TrP treatment has been shown to reduce sensitization-associated symptomatology in nociplastic pain conditions, e.g., fibromyalgia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.