Bacterial Virulence and Prevention for Human Spaceflight.

Hakim Ullah Wazir, Pooja Narang, Giulia Silvani, Christine Mehner, Kate Poole, Catherine Burke, Joshua Chou

Abstract read

In one paragraph

Article in Life (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

MAPK/PMK-1 innate immune signaling protects the nematode Caenorhabditis elegans from increased intestinal colonization in an animal host-pathogen model in space.NPJ microgravity · 2026
Article
Impact of simulated microgravity in short-term evolution of an RNA bacteriophage.Frontiers in microbiology · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hakim Ullah WazirSchool of Biomedical Engineering, Faculty of Engineering and Information Technology, University of Technology Sydney, Ultimo, NSW 2007, Australia.

Pooja NarangSchool of Life Sciences, Faculty of Science, University of Technology Sydney, Ultimo, NSW 2007, Australia.

Giulia SilvaniSchool of Material Science and Engineering, University of New South Wales, Sydney, NSW 2052, Australia.

Christine MehnerDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Jacksonville, FL 32224, USA.

Kate PooleEMBL Australia Node in Single Molecule Science, Faculty of Medicine, School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia.

Catherine BurkeSchool of Life Sciences, Faculty of Science, University of Technology Sydney, Ultimo, NSW 2007, Australia.

Joshua ChouSchool of Biomedical Engineering, Faculty of Engineering and Information Technology, University of Technology Sydney, Ultimo, NSW 2007, Australia.ORCID 0000-0002-7472-8016

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With the advancement in reusable rocket propulsion technology, space tourist trips into outer space are now becoming a possibility at a cost-effective rate. As such, astronauts will face a host of health-related challenges, particularly on long-duration space missions where maintaining a balanced healthy microbiome is going to be vital for human survival in space exploration as well as mission success. The human microbiome involves a whole list of micro-organisms that reside in and on the human host, and plays an integral role in keeping the human host healthy. However, imbalances in the microbiome have been directly linked to many human diseases. Research findings have clearly shown that the outer space environment can directly affect the normal microbiome of astronauts when the astronaut is exposed to the microgravity environment. In this study, we show that the simulation of microgravity on earth can mimic the outer space microgravity environment.

Indexed as

antibacterial coatingbacteriacell viabilitygentamicinmicrobiomemicrogravityproliferationS. aureusspacevirulence

Identifiers

PMID36983812

DOI10.3390/life13030656

PMCPMC10058866

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.