Evidence map›Paper›PMID 36983783›Full record

ArticleLife (Basel, Switzerland)2023

Serum Cytokines as Biomarkers in Heart Failure with Preserved Ejection Fraction and Sleep Apnea: A Prospective Cohort Study.

Alexey Yakovlev, Alexander Teplyakov, Elena Grakova, Sergey Shilov, Natalia Yakovleva, Kristina Kopeva, Valery Shirinsky, Ivan Shirinsky

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Alexey YakovlevDepartment of Therapy, Hematology and Transfusiology, Novosibirsk State Medical University, Krasny Prospect, 52, 630091 Novosibirsk, Russia.
Alexander TeplyakovCardiology Research Institute, Tomsk National Research Medical Center (NRMC), Kievskaya Str., 111a, 634012 Tomsk, Russia.
Elena GrakovaDepartment of Myocardial Pathology, Cardiology Research Institute, Tomsk National Research Medical Center (NRMC), Kievskaya Str., 111a, 634012 Tomsk, Russia.ORCID 0000-0003-4019-3735
Sergey ShilovDepartment of Pathological Physiology and Clinical Pathophysiology, Novosibirsk State Medical University, Krasny Prospect, 52, 630091 Novosibirsk, Russia.
Natalia YakovlevaDepartment of Policlinic Therapy and General Medical Practice, Novosibirsk State Medical University, Krasny Prospect, 52, 630091 Novosibirsk, Russia.
Kristina KopevaDepartment of Myocardial Pathology, Cardiology Research Institute, Tomsk National Research Medical Center (NRMC), Kievskaya Str., 111a, 634012 Tomsk, Russia.ORCID 0000-0002-2285-6438
Valery ShirinskyLaboratory of Clinical Immunopharmacology, Federal State Budgetary Scientific Institution, Research Institute of Fundamental and Clinical Immunology, 6 Zalesskogo Str., 630099 Novosibirsk, Russia.
Ivan ShirinskyLaboratory of Clinical Immunopharmacology, Federal State Budgetary Scientific Institution, Research Institute of Fundamental and Clinical Immunology, 6 Zalesskogo Str., 630099 Novosibirsk, Russia.
Novosibirsk State Medical University · RUTomsk National Research Medical Center · RUResearch Institute of Fundamental and Clinical Immunology · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heart failure with preserved ejection fraction (HFpEF) and obstructive sleep apnea (OSA) frequently co-occur and this comorbidity represents a separate phenotype of HFpEF. While many research attempts are focused on biomarkers of HFpEF, currently, there is a lack of validated biomarkers of HFpEF and OSA. In this study, we aimed to evaluate prognostic significance of several serum cytokines in patients with HFpEF and OSA. The patients with HFpEF and OSA were recruited from the Sleep Apnea Center of Novosibirsk, Russian Federation and followed up for 12 months. The main analyzed outcomes were five-point major adverse cardiovascular events (MACE) and the 6-min walk test (6MWT). The analyzed cytokines were circulating IL-6, IL-10, and VEGF measured at baseline. We recruited 77 male patients with HFpEF and OSA, the data of 71 patients were available for analyses. Patients who developed MACE had four-fold elevated concentrations of serum IL-10. There was no association between baseline cytokine levels and longitudinal changes in 6MWT. Circulating IL-10 levels are positively associated with MACE in men with HFpEF and OSA and thus may be a potential prognostic biomarker in this subgroup of patients. These results should be confirmed in larger studies encompassing both males and females.

Indexed as

biomarkerscomorbiditycytokinesheart failureHFHFpEFobstructiveOSAphenotypeprognosissleep apnea

Identifiers

PMID36983783
PMCPMC10051341
OpenAlexW4321789953

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.