Evidence map›Paper›PMID 36983748›Full record

ArticleJournal of personalized medicine2023

The Association of Four Natural Molecules-EGCG, Folic Acid, Vitamin B12, and HA-To Counteract HPV Cervical Lesions: A Case Report.

Giovanni Grandi, Laura Botticelli, Pietro Di Fraia, Carla Babalini, Meris Masini, Vittorio Unfer

Registry-linked trialOpen access · goldAbstract readCase Reports
In one paragraph

Article in Journal of personalized medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07697196 (An Interventional Study Evaluating the Effect of Epigallocatechin Gallate), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07697196 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

An Interventional Study Evaluating the Effect of Epigallocatechin Gallate (EGCG), Folic Acid (FA), Vitamin B12 (B12) and Hyaluronic Acid (HA) in Affecting the DNA Integration of Human Papilloma Virus (HPV) in Women With Persistent Infection

TypeinterventionalSponsorIRCCS San RaffaeleRan2026 to 2028Enrolled42ConditionsHPV Infection, HPV Integration, HPV Disease, HPV Genital InfectionArmsEpigallocatechin gallate (EGCG), Folic Acid (FA), Vitamin B12 (B12), and Hyaluronic Acid (HA)
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Giovanni GrandiDepartment of Medical and Surgical Sciences for Mother, Child and Adult, Obstetrics and Gynecology Unit, University of Modena and Reggio Emilia, Azienda Ospedaliero Universitaria Policlinico, 41125 Modena, Italy.ORCID 0000-0002-3567-3278
Laura BotticelliDepartment of Pathology, Azienda Ospedaliero Universitaria Policlinico, University of Modena and Reggio Emilia, 41125 Modena, Italy.
Pietro Di FraiaDi Fraia Laboratori s.r.l., 00034 Colleferro, Italy.
Carla BabaliniDi Fraia Laboratori s.r.l., 00034 Colleferro, Italy.
Meris MasiniDepartment of Medical and Surgical Sciences for Mother, Child and Adult, Obstetrics and Gynecology Unit, University of Modena and Reggio Emilia, Azienda Ospedaliero Universitaria Policlinico, 41125 Modena, Italy.
Vittorio UnferUniCamillus-Saint Camillus International University of Health Sciences, 00131 Rome, Italy.
University of Modena and Reggio Emilia · ITSaint Camillus International University of Health and Medical Sciences · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Precancerous lesions of the uterine cervix, due to HPV infections, are still today a great medical challenge. This clinical case highlighted the effectiveness of epigallocatechin gallate (EGCG), vitamin B12, folic acid, and hyaluronic acid (HA) in counteracting HPV lesions in a 39-year-old patient with a long history of viral persistence, cervical lesions of various degree, and several unsuccessful surgical approaches. After eight weeks of treatment, both the histological and cytological analyses revealed only a chronic cervicitis without any malignant lesions or cellular dysplasia, thus reducing the urgency of an invasive surgery, a total hysterectomy.

Indexed as

cervical lesionsEGCGfolic acidHAHPVvitamin B12

Identifiers

PMID36983748
PMCPMC10051187
OpenAlexW4353064112

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.