ReviewJournal of clinical medicine2023
Vesicoureteral Reflux and Innate Immune System: Physiology, Physiopathology, and Clinical Aspects.
Review in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- The Study of Microbiome of the Female Genital Area in Relation to Pelvic Floor Dysfunction: A Systematic Review.International urogynecology journal · 2024Pooled it
- Article
- Coexistence of PYCR1-related cutis laxa and bilateral grade V vesicoureteral reflux with reflux nephropathy: A case report.SAGE open medical case reports · 2026Article
- Urodynamic Evaluation: Is It Useful for Vesicoureteral Reflux Management?Journal of clinical medicine · 2025Article
- Neurogenic Bladder in Children with Myelomeningocele.Diseases (Basel, Switzerland) · 2025Review
- A Systematic Review of the Accuracy and Reliability of Pyuria in Diagnosing Pediatric Urinary Tract Infections.Cureus · 2025Review
- Tubulointerstitial nephritis in children and adolescents.Pediatric nephrology (Berlin, Germany) · 2025Review
- The Evaluation of Serum KIM-1 in a Pediatric Cohort of Renal Transplantation-A Pilot Study.Children (Basel, Switzerland) · 2025Article
- Nadir Creatinine in Congenital Anomalies of the Kidney and Urinary Tract (CAKUT): A Single-Center Experience.Children (Basel, Switzerland) · 2024Article
- The Utility of Noninvasive Urinary Biomarkers for the Evaluation of Vesicoureteral Reflux in Children.International journal of molecular sciences · 2023Article
- Urinary Tract Infections: Prevention, Diagnosis, and Treatment.Journal of clinical medicine · 2023Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vesicoureteral reflux represents one of the most concerning topics in pediatric nephrology due to its frequency, clinical expression with the potential to evolve into chronic kidney disease, and last but not least, its socio-economic implications. The presence of vesicoureteral reflux, the occurrence of urinary tract infections, and the development of reflux nephropathy, hypertension, chronic kidney disease, and finally, end-stage renal disease represent a progressive spectrum of a single physiopathological condition. For the proper management of these patients with the best clinical outcomes, and in an attempt to prevent the spread of uropathogens' resistance to antibacterial therapy, we must better understand the physiopathology of urinary tract infections in patients with vesicoureteral reflux, and at the same time, we should acknowledge the implication and response of the innate immune system in this progressive pathological condition. The present paper focuses on theoretical aspects regarding the physiopathology of vesicoureteral reflux and the interconditionality between urinary tract infections and the innate immune system. In addition, we detailed aspects regarding cytokines, interleukins, antimicrobial peptides, and proteins involved in the innate immune response as well as their implications in the physiopathology of reflux nephropathy. New directions of study should focus on using these innate immune system effectors as diagnostic and therapeutic tools in renal pathology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.