ArticleJournal of clinical medicine2023
Effect of Different Sealers on the Cytocompatibility and Osteogenic Potential of Human Periodontal Ligament Stem Cells: An In Vitro Study.
Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- Ex-vivo evaluation of clinically-set hydraulic sealers used with different canal dryness protocols and obturation techniques: a randomized clinical trial.Clinical oral investigations · 2024Trial
- Exploring vitamin K2 and B12 as bioactive micronutrients for dentin conditioning in regenerative endodontics procedures.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Cytocompatibility, osteogenic potential, antibacterial and antibiofilm efficacy of a calcium-silicate-based intracanal medication.Odontology · 2026Article
- Single-Cone vs. Carrier-Based Root Canal Obturation with a Calcium-Silicate-Based Sealer: An In Vitro µ-CT Analysis.Biomimetics (Basel, Switzerland) · 2026Article
- Ultrasonic activation improves bond strength of calcium silicate-based sealers to dentin: an in vitro study.BMC oral health · 2026Article
- Root Canal Filling of Teeth with Open Apex Using Different Techniques, Low-Temperature Gutta-Percha Points, and Bioceramic Sealers.Brazilian dental journal · 2026Article
- Osteogenic Potential of Various Premixed Hydraulic Calcium Silicate-Based Sealers on Human Bone Marrow Stem Cells.Materials (Basel, Switzerland) · 2025Article
- In vitro Evaluation of Cytotoxicity, Biocompatibility, and Osteogenic Effect of Two Calcium Silicate Sealers Compared with AH Plus Jet.European journal of dentistry · 2025Article
- Evaluation of osteoconductivity and inflammatory response of a resin-based and a resin-free calcium silicate sealer: an in vivo study.Clinical oral investigations · 2025Article
- Effect of TheraCal PT and Biodentine on inflammatory cell infiltration and hard tissue formation after pulpotomy in inflamed or healthy rat molars.Clinical oral investigations · 2025Article
- Effect of Bio MTA plus & ProRoot MTA pulp capping materials on the regenerative properties of human dental pulp stem cells.Scientific reports · 2025Article
- Cytocompatibility, Antibacterial, and Anti-Biofilm Efficacy of Grape Seed Extract and Quercetin Hydrogels Against a Mature Endodontic Biofilm Ex Vivo Model.Journal of clinical medicine · 2024Article
- Article
- Article
- Quality of different obturation techniques to fill perforating internal root resorption: a micro-computed tomographic study.BMC oral health · 2024Article
- Comparative bioactivity and immunomodulatory potential of the new Bioroot Flow and AH Plus Bioceramic sealer: An in vitro study on hPDLSCs.Clinical oral investigations · 2024Article
- Physicochemical properties of AH plus bioceramic sealer, Bio-C Sealer, and ADseal root canal sealer.Head & face medicine · 2024Article
- Evaluation of dental pulp stem cells response to flowable nano-hybrid dental composites: A comparative analysis.PloS one · 2024Article
- Enhancing the anticancer potential of metformin: fabrication of efficient nanospanlastics,International journal of pharmaceutics: X · 2023Article
- Thermal, chemical and physical analysis of VDW.1Seal, Fill Root ST, and ADseal root canal sealers.Scientific reports · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is tendency for unavoidable sealer extrusion in some clinical cases. This might adversely affect host stem cells and affect healing. This study aimed to investigate the effect of different sealers on the cytocompatibility and osteogenic potential of human periodontal ligament stem cells (
methodsThe cytotoxic effect of the extracted elutes of VDW.1Seal (VDW.1), Endosequence BC Sealer HiFlow (ES), GuttaFlow-2 (GF), and ADSeal (AD-S) on the
resultsGF had a significantly higher percentage of viable cells. The cell migration assay showed that GF demonstrated the lowest open wound area percentage. GF and AD-S showed the highest calcium nodule deposition. GF demonstrated higher ALP activity than ES. Expression of RUNX2 and OC genes was similar for all sealers, while OPG gene expression was significantly higher for VDW.1 and GF. ES and AD-S displayed the highest pH values on day 1. Calcium ion release of ES and VDW.1 was significantly the highest.
conclusionsGuttaFlow-2 and VDW.1Seal sealers have favorable behavior toward host stem cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.