Evidence map›Paper›PMID 36983338›Full record

ArticleJournal of clinical medicine2023

Olfaction and Anxiety Are Differently Associated in Men and Women in Cognitive Physiological and Pathological Aging.

Filippo Cieri, Nicoletta Cera, Aaron Ritter, Dietmar Cordes, Jessica Zoe Kirkland Caldwell

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Filippo CieriDepartment of Neurology, Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV 89106, USA.
Nicoletta CeraLaboratory of Neuropsychophysiology, Faculty of Psychology and Education Sciences, University of Porto, 4200-135 Porto, Portugal.ORCID 0000-0002-2702-8789
Aaron RitterDepartment of Neurology, Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV 89106, USA.
Dietmar CordesDepartment of Neurology, Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV 89106, USA.
Jessica Zoe Kirkland CaldwellDepartment of Neurology, Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV 89106, USA.
Cleveland Clinic · USUniversidade do Porto · PT

Funding

Renewal of Centers of Biomedical Research Excellence (COBRE) (Phase 2) CNTN - ResubmissionP20GM109025 · NIGMS · CLEVELAND CLINIC FOUNDATION · PI Robert J. Fox, Jefferson Kinney · 2015 to 2026
$22.8M
NVEDARC Clinical CoreP20AG068053 · NIA · CLEVELAND CLINIC FOUNDATION · PI WINT, DYLAN · 2020 to 2022
$3.3M
Machine and deep learning for finding multimodal imaging biomarkers in prodromal ADRF1AG071566 · NIA · CLEVELAND CLINIC LERNER COM-CWRU · PI CORDES, DIETMAR, LOWE, MARK J · 2021 to 2021
$2.3M
Interactions of Sex and Gender Factors in Risk for Alzheimers Disease: Links Between Stress, Neural Activity, Inflammation, and MemoryR01AG074392 · NIA · CLEVELAND CLINIC LERNER COM-CWRU · PI KIRKLAND CALDWELL, JESSICA · 2021 to 2024
$1.8M
FCT FCT-PTDC/PSI-GER/30520/2017; NORTE-01-0145-FEDER-030520National Institute of General Medical Sciences of the National Institutes of Health 5P20GM109025Nevada Exploratory Alzheimer's Disease Research Center NVeADRC; P20-AG068053NIA NIH HHS P20 AG068053NIA NIH HHS R01 AG074392NIA NIH HHS R01-AG074392 and P20-AG068053NIA NIH HHS RF1 AG071566NIA NIH HHS RF1AG071566NIGMS NIH HHS P20 GM109025
6 · The paper itself

Abstract

backgroundOlfaction impairment in aging is associated with increased anxiety. We explored this association in cognitively healthy controls (HCs), Mild Cognitive Impairment (MCI) and Parkinson's disease (PD) patients. Both olfaction and anxiety have sex differences, therefore we also investigated these variances.

objectivesInvestigate the association of olfaction with anxiety in three distinct clinical categories of aging, exploring the potential role of sex.

methods117 subjects (29 HCs, 43 MCI, and 45 PD patients) were assessed for olfaction and anxiety. We used regression models to determine whether B-SIT predicted anxiety and whether sex impacted that relationship.

resultsLower olfaction was related to greater anxiety traits in all groups (HCs: DISCUSSION: Olfaction and anxiety are correlated in all three distinct diagnostic categories, but differently in men and women.

Indexed as

aginganxietyolfactionParkinson’s diseasesex difference

Identifiers

PMID36983338
PMCPMC10054317
OpenAlexW4327737258

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.