ReviewJournal of clinical medicine2023
The Biology of Stress Intolerance in Patients with Chronic Pain-State of the Art and Future Directions.
Review in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07036354 (Evaluation of the Effects of Human-Animal Interaction on Physiological and Psychological Anxiety Markers in Graduate Students), which is not on this map. Cited by 44 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of the Effects of Human-Animal Interaction on Physiological and Psychological Anxiety Markers in Graduate Students
Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- The stress-fascia-pain axis in myofascial pain syndrome: a mechanistic integrative review and conceptual synthesis.Frontiers in pain research (Lausanne, Switzerland) · 2026Pooled it
- The effect of the Emotional Freedom Technique (EFT) on pain and depression in cancer patients: a randomized controlled trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Trial
- Stress Urinary Incontinence as a Chronic Stress Model: Clinical Evidence and Emerging Epigenetic Implications for Mental Disorders.Biomedicines · 2026Article
- Neurobiological and Neuroimmune Mechanisms Linking Chronic Pain, Sleep Disturbances and Mental Health Disorders.International journal of molecular sciences · 2026Review
- Cancer-related pain: A bidirectional modulator of cancer progression.Clinical and translational medicine · 2026Review
- The Potential Pathway Among Self-Focused Attention, Rumination, Perceived Stress and Female Psychosomatic Symptoms.Behavioral sciences (Basel, Switzerland) · 2026Article
- The effect of psychological stress on masticatory muscle electromyography-a scoping review.Journal of oral & facial pain and headache · 2026Article
- Novel therapeutic strategies for osteoarthritis: from mechanistic insights to precision medicine.Bone research · 2026Review
- Targeted Real-Time Assessment of Chronic Pain (TRAC-Pain) in Youth: Protocol for a Digital Biosignature Development Through a Prospective Observational Cohort Study.JMIR research protocols · 2026Observational
- Multidimensional analysis of the clinical spectrum and symptom burden of unexplained myofascial pain.medRxiv : the preprint server for health sciences · 2026Article
- Nocturnal Autonomic Nervous System Dynamics and Chronic Painful Temporomandibular Disorders.JDR clinical and translational research · 2026Observational
- Impact of adverse life experiences on pain, depression, anxiety, and comorbidities: a youth longitudinal sample.Pain reports · 2026Article
- Genetic subtraction reveals divergent pathways and targets in anxiety-related and anxiety-independent TMD.The journal of headache and pain · 2026Article
- The Relationship Between Pain and Depression in Fibromyalgia: Structural Equation Modeling and Network Analysis.International journal of environmental research and public health · 2026Article
- Therapeutic Patient Education in Adults with Chronic Lower Limb Musculoskeletal Pain: A Scoping Review.Healthcare (Basel, Switzerland) · 2026Review
- Modulatory role of endogenous adrenaline in propofol-related nociceptive responses in rats.Frontiers in pharmacology · 2026Article
- Quality of life and work status in patients treated for neurogenic thoracic outlet syndrome via the microsurgical supraclavicular approach - an observational study.Brain & spine · 2026Article
- Prenatal alcohol exposure promotes nerve injury-induced pathological pain following morphine treatment via NLRP3-mediated peripheral and central proinflammatory immune actions.Brain, behavior, and immunity · 2025Article
- Looking Inwards: The Role of Self-Care, Self-Management and Self-Healing in Musculoskeletal Pain.Musculoskeletal care · 2025Article
- Investigating the Association Between Central Sensitization and Breathing Pattern Disorders.Biomedicines · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Stress has been consistently linked to negative impacts on physical and mental health. More specifically, patients with chronic pain experience stress intolerance, which is an exacerbation or occurrence of symptoms in response to any type of stress. The pathophysiological mechanisms underlying this phenomenon remain unsolved. In this state-of-the-art paper, we summarised the role of the autonomic nervous system (ANS) and hypothalamus-pituitary-adrenal (HPA) axis, the two major stress response systems in stress intolerance. We provided insights into such mechanisms based on evidence from clinical studies in both patients with chronic pain, showing dysregulated stress systems, and healthy controls supported by preclinical studies, highlighting the link between these systems and symptoms of stress intolerance. Furthermore, we explored the possible regulating role for (epi)genetic mechanisms influencing the ANS and HPA axis. The link between stress and chronic pain has become an important area of research as it has the potential to inform the development of interventions to improve the quality of life for individuals living with chronic pain. As stress has become a prevalent concern in modern society, understanding the connection between stress, HPA axis, ANS, and chronic health conditions such as chronic pain is crucial to improve public health and well-being.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.