ArticleJournal of clinical medicine2023
The Impact of Depression and Anxiety on Adult Cancer Patients' Health-Related Quality of Life.
Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 4 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- The effectiveness of guided imagery on psychological outcomes and quality of life in cancer patients: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Pooled it
- Psychosocial factors associated with quality of life in cancer patients undergoing treatment: an umbrella review.Health and quality of life outcomes · 2025Pooled it
- Global research and emerging trends in depression in lung cancer: a bibliometric and visualized study from 2014 to 2024.Frontiers in oncology · 2025Pooled it
- Systematic review of associations between anxiety, depression, and functional/biological aging among cancer survivors.JNCI cancer spectrum · 2024Pooled it
- Anxiety, depression, quality of life and the mediating role of psychological flexibility: A study on Spanish cancer patients.Scientific reports · 2025Trial
- Article
- Psychological impact of hospital admission in cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Observational
- Comparing Quality of Life and Well-Being Among Patients with Chronic Diseases.Healthcare (Basel, Switzerland) · 2026Article
- Prevalence of Anxiety and Depression and Their Association with Health-Related Quality of Life Among Oncology Patients in Iraq: A Cross-Sectional Study.Medicina (Kaunas, Lithuania) · 2026Article
- The Experience of Depression in Older Adults With Cancer: A Qualitative Descriptive Analysis.Psycho-oncology · 2026Article
- Older Adult Cancer Survivors' Functional Limitations and Determinants of Health: Evidence from the 2021 National Health Interview Survey.Journal of clinical medicine · 2026Article
- Psychological Resilience and Associated Factors in Cancer Patients: A Cross-Sectional Analysis.Cancer reports (Hoboken, N.J.) · 2026Article
- Depression and anxiety symptoms and their association with quality of life in patients with colorectal cancer: A cross-sectional study.The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa · 2026Article
- Recognizing anxiety and depression in cancer patients based on speech and facial expressions.Frontiers in psychiatry · 2026Article
- Incidence of new-onset depression after colorectal cancer diagnosis and associated mortality: a population-based cohort study.BMJ oncology · 2026Article
- The growing and urgent need for interventions to mitigate cancer-related stigma in sub-Saharan Africa.Global mental health (Cambridge, England) · 2026Review
- Quality of life and its association with anxiety, depression, and clinical factors among patients with metastatic cancer attending oncology centers in Northwest Ethiopia.Palliative care and social practice · 2026Article
- Effect of radical prostatectomy on anxiety, depression, and quality of life in patients diagnosed with prostate cancer.World journal of psychiatry · 2025Article
- Article
- Association of Quality of Life Domains and Clinical Symptoms in Patients With Familial Cerebral Cavernous Malformation.Journal of the American Heart Association · 2025Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundCancer patients are at high risk for mental illness and, in turn, poorer health-related quality of life. This study used nationally representative United States (US) data to examine nuances of the impact of depression and/or anxiety on HRQoL in different cancer groups (e.g., cancer only, cancer and depression, cancer and anxiety, cancer and both conditions).
methodsAdult patients aged 18 years and older with a cancer diagnosis were identified from the Medical Expenditure Panel Survey data for 2012-2016. HRQoL was measured using the SF-12 Physical and Mental Component Summary (PCS & MCS) scores. Multivariate linear regressions were used, controlling for a multitude of factors.
resultsAround 12% of the 1712 identified patients with cancer had depression, 13% had anxiety, and 8.4% had both depression and anxiety. Patients with comorbid depression and anxiety had the lowest mean scores of both PCS and MCS compared to patients in other groups. In addition, cancer patients with either depression and/or anxiety were more likely to have lower MCS scores compared to those with cancer only (depression: β = -6.554; anxiety: β = -3.916; both conditions: β = -11.759,
conclusionsThe psychological burden of cancer is immense, with a substantial impact on patients' HRQoL. Routine screening for depression and anxiety, especially for women and those with low poverty status and comorbidities, should be conducted by healthcare providers to identify those with high odds of having a lower HRQoL. Additionally, early psychiatric interventions, such as psychotherapy and prescription drugs, may positively impact patients' mental well-being and HRQoL.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.