Evidence map›Paper›PMID 36983111›Full record

ArticleJournal of clinical medicine2023

The Impact of Thrombophilic Factors on Disease Progression in Children with Biliary Atresia-A Single-Centre Cohort Study.

Johanna Ohlendorf, Hella Kiene, Jessica Wiegandt, André Karch, Veronika K Jaeger, Tobias Laue, Norman Junge, Frauke Mutschler, Imeke Goldschmidt, Eva-Doreen Pfister and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 2 countries.

Johanna OhlendorfPaediatric Gastroenterology, Hepatology and Liver Transplantation, Hanover Medical School, 30625 Hanover, Germany.ORCID 0000-0002-7994-7656
Hella KienePaediatric Gastroenterology, Hepatology and Liver Transplantation, Hanover Medical School, 30625 Hanover, Germany.
Jessica WiegandtPaediatric Gastroenterology, Hepatology and Liver Transplantation, Hanover Medical School, 30625 Hanover, Germany.
André KarchInstitute of Epidemiology and Social Medicine, University of Muenster, 48149 Muenster, Germany.
Veronika K JaegerInstitute of Epidemiology and Social Medicine, University of Muenster, 48149 Muenster, Germany.ORCID 0000-0002-6913-0976
Tobias LauePaediatric Gastroenterology, Hepatology and Liver Transplantation, Hanover Medical School, 30625 Hanover, Germany.
Norman JungePaediatric Gastroenterology, Hepatology and Liver Transplantation, Hanover Medical School, 30625 Hanover, Germany.ORCID 0000-0002-3099-2667
Frauke MutschlerPaediatric Gastroenterology, Hepatology and Liver Transplantation, Hanover Medical School, 30625 Hanover, Germany.
Imeke GoldschmidtPaediatric Gastroenterology, Hepatology and Liver Transplantation, Hanover Medical School, 30625 Hanover, Germany.ORCID 0000-0002-7648-9127
Eva-Doreen PfisterPaediatric Gastroenterology, Hepatology and Liver Transplantation, Hanover Medical School, 30625 Hanover, Germany.
Christoph LeiskauDepartment of Paediatrics and Adolescent Medicine, University Medical Centre Goettingen, Georg August University, 37075 Goettingen, Germany.
Claus PetersenPaediatric Surgery, Hannover Medical School, 30625 Hanover, Germany.ORCID 0000-0002-1789-7163
Omid Madadi-SanjaniPaediatric Surgery, Hannover Medical School, 30625 Hanover, Germany.ORCID 0000-0002-7239-8973
Joachim Friedrich KueblerPaediatric Surgery, Hannover Medical School, 30625 Hanover, Germany.
Juliane Katharina GötzPaediatric Gastroenterology, Hepatology and Liver Transplantation, Hanover Medical School, 30625 Hanover, Germany.
Ulrich BaumannPaediatric Gastroenterology, Hepatology and Liver Transplantation, Hanover Medical School, 30625 Hanover, Germany.
Medizinische Hochschule Hannover · DEUniversity of Göttingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epidemiological evidence suggests that thrombophilic factors, including male sex, non-O blood type, MTHFRnt677TT mutation, factor V Leiden G1691A mutation, and prothrombin G20210A polymorphism, may contribute to the progression of fibrosis and occurrence of portal vein thrombosis in liver disease. We retrospectively investigated the effect of potentially thrombophilic factors on native liver survival as a patient-relevant endpoint of disease progression in a cohort of 142 children being followed up for biliary atresia at Hannover Medical School from April 2017 to October 2019. No significant association could be determined. There was no evidence for relevant differences in native liver survival for the Factor V Leiden G1691A mutation (hazard ratio [HR] = 0.86, 95% confidence interval [CI] 0.38-1.98,

Indexed as

biliary atresiachildliver cirrhosismaleMTHFRnt677TTpaediatric liver transplantationrisk factorsthrombophilia

Identifiers

PMID36983111
PMCPMC10059690
OpenAlexW4323568356

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.