Evidence map›Paper›PMID 36983085›Full record

ArticleInternational journal of molecular sciences2023

Generation and Next-Generation Sequencing-Based Characterization of a Large Human Combinatorial Antibody Library.

Hye Lim Choi, Ha Rim Yang, Ha Gyeong Shin, Kyusang Hwang, Ji Woong Kim, Ji Hyun Lee, Taehoon Ryu, Yushin Jung, Sukmook Lee

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Hye Lim ChoiDepartment of Biopharmaceutical Chemistry, Kookmin University, Seoul 02707, Republic of Korea.
Ha Rim YangDepartment of Biopharmaceutical Chemistry, Kookmin University, Seoul 02707, Republic of Korea.
Ha Gyeong ShinDepartment of Biopharmaceutical Chemistry, Kookmin University, Seoul 02707, Republic of Korea.
Kyusang HwangDepartment of Biopharmaceutical Chemistry, Kookmin University, Seoul 02707, Republic of Korea.ORCID 0009-0007-9631-4264
Ji Woong KimDepartment of Chemistry, Kookmin University, Seoul 02707, Republic of Korea.ORCID 0000-0002-1589-2449
Ji Hyun LeeDepartment of Biopharmaceutical Chemistry, Kookmin University, Seoul 02707, Republic of Korea.
Taehoon RyuATG Lifetech Inc., Seoul 08507, Republic of Korea.
Yushin JungATG Lifetech Inc., Seoul 08507, Republic of Korea.
Sukmook LeeDepartment of Biopharmaceutical Chemistry, Kookmin University, Seoul 02707, Republic of Korea.ORCID 0000-0002-9119-7317
Kookmin University · KRGL PharmTech (South Korea) · KR

Funding

Korea Health Technology R&D Project of the Korea Health Industry Development Institute HI22C0360
6 · The paper itself

Abstract

Antibody phage display is a key technology for the discovery and development of target-specific monoclonal antibodies (mAbs) for use in research, diagnostics, and therapy. The construction of a high-quality antibody library, with larger and more diverse antibody repertoires, is essential for the successful development of phage display-derived mAbs. In this study, a large human combinatorial single-chain variable fragment library (1.5 × 10

Indexed as

Epstein-Barr Virus InfectionsPeptide LibraryAntibodies, MonoclonalHerpesvirus 4, HumanHigh-Throughput Nucleotide SequencingHumansLeukocytes, MononuclearAntibodies, MonoclonalPeptide Libraryantibody libraryhuman monoclonal antibodynext-generation sequencingphage displaysomatic hypermutation

Identifiers

PMID36983085
PMCPMC10057307
OpenAlexW4360616520

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.