Evidence map›Paper›PMID 36983008›Full record

ArticleInternational journal of molecular sciences2023

Oxygen-Releasing Hyaluronic Acid-Based Dispersion with Controlled Oxygen Delivery for Enhanced Periodontal Tissue Engineering.

Lena Katharina Müller-Heupt, Nadine Wiesmann-Imilowski, Sofia Schröder, Jonathan Groß, Pablo Cores Ziskoven, Philipp Bani, Peer Wolfgang Kämmerer, Eik Schiegnitz, Anja Eckelt, John Eckelt and 5 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Macrophage adaptation to hypoxia: metabolism, migration, and phagocytosis.Frontiers in cellular and infection microbiology · 2025
    Article
  3. Review
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Lena Katharina Müller-HeuptDepartment of Oral and Maxillofacial Surgery, University Medical Center Mainz, Augustusplatz 2, 55131 Mainz, Germany.ORCID 0000-0002-8259-3959
Nadine Wiesmann-ImilowskiDepartment of Oral and Maxillofacial Surgery, University Medical Center Mainz, Augustusplatz 2, 55131 Mainz, Germany.ORCID 0000-0001-5661-6953
Sofia SchröderDepartment of Oral and Maxillofacial Surgery, University Medical Center Mainz, Augustusplatz 2, 55131 Mainz, Germany.
Jonathan GroßDepartment of Chemistry, Johannes Gutenberg-University, Duesbergweg 10-14, 55128 Mainz, Germany.
Pablo Cores ZiskovenDepartment of Periodontology and Operative Dentistry, University Medical Center Mainz, Augustusplatz 2, 55131 Mainz, Germany.ORCID 0009-0006-8257-077X
Philipp BaniDepartment of Periodontology and Operative Dentistry, University Medical Center Mainz, Augustusplatz 2, 55131 Mainz, Germany.
Peer Wolfgang KämmererDepartment of Oral and Maxillofacial Surgery, University Medical Center Mainz, Augustusplatz 2, 55131 Mainz, Germany.ORCID 0000-0002-1671-3764
Eik SchiegnitzDepartment of Oral and Maxillofacial Surgery, University Medical Center Mainz, Augustusplatz 2, 55131 Mainz, Germany.
Anja EckeltWEE-Solve GmbH, Auf der Burg 6, 55130 Mainz, Germany.
John EckeltWEE-Solve GmbH, Auf der Burg 6, 55130 Mainz, Germany.
Ulrike RitzDepartment of Orthopaedics and Traumatology, University Medical Center Mainz, Langenbeckstr. 1, 55131 Mainz, Germany.ORCID 0000-0001-8936-3227
Till OpatzDepartment of Chemistry, Johannes Gutenberg-University, Duesbergweg 10-14, 55128 Mainz, Germany.ORCID 0000-0002-3266-4050
Bilal Al-NawasDepartment of Oral and Maxillofacial Surgery, University Medical Center Mainz, Augustusplatz 2, 55131 Mainz, Germany.
Christopher V SynatschkeMax Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany.ORCID 0000-0002-4259-6696
James DeschnerDepartment of Periodontology and Operative Dentistry, University Medical Center Mainz, Augustusplatz 2, 55131 Mainz, Germany.
Johannes Gutenberg University Mainz · DEMax Planck Institute for Polymer Research · DE

Funding

Federal Ministry of Education and Research Go-Bio 16LW0128
6 · The paper itself

Abstract

Periodontitis is a chronic biofilm-associated inflammatory disease of the tooth-supporting tissues that causes tooth loss. It is strongly associated with anaerobic bacterial colonization and represents a substantial global health burden. Due to a local hypoxic environment, tissue regeneration is impaired. Oxygen therapy has shown promising results as a potential treatment of periodontitis, but so far, local oxygen delivery remains a key technical challenge. An oxygen (O

Indexed as

Hyaluronic AcidPeriodontitisHumansOxygenPorphyromonas gingivalisTissue EngineeringHyaluronic AcidOxygenangiogenesisbiopolymerhyaluronic acidhypoxiaoxygenperiodontitisperoxidestissue engineeringtissue regeneration

Identifiers

PMID36983008
PMCPMC10059003
OpenAlexW4328103587

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.