Evidence map›Paper›PMID 36982935›Full record

ReviewInternational journal of molecular sciences2023

Hematopoietic Stem Cells and the Immune System in Development and Aging.

Daniil Shevyrev, Valeriy Tereshchenko, Tatiana N Berezina, Stanislav Rybtsov

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 44 citations in OpenAlex.

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  14. scFocus: Detecting branching probabilities in single-cell data with SAC.Computational and structural biotechnology journal · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Daniil ShevyrevCentre for Cell Technology and Immunology, Sirius University of Science and Technology, Sirius, 354340 Sochi, Russia.ORCID 0000-0002-7084-081X
Valeriy TereshchenkoCentre for Cell Technology and Immunology, Sirius University of Science and Technology, Sirius, 354340 Sochi, Russia.
Tatiana N BerezinaDepartment of Scientific Basis of Extreme Psychology, Moscow State University of Psychology and Education, 127051 Moscow, Russia.ORCID 0000-0002-8188-237X
Stanislav RybtsovCentre for Cell Technology and Immunology, Sirius University of Science and Technology, Sirius, 354340 Sochi, Russia.ORCID 0000-0001-7786-1878
Sirius University of Science and Technology · RUMoscow State University of Psychology & Education · RU

Funding

Russian Science Foundation 19-18-00058-P
6 · The paper itself

Abstract

Hematopoietic stem cells (HSCs) support haematopoiesis throughout life and give rise to the whole variety of cells of the immune system. Developing in the early embryo, passing through the precursor stage, and maturing into the first HSCs, they undergo a fairly large number of divisions while maintaining a high regenerative potential due to high repair activity. This potential is greatly reduced in adult HSCs. They go into a state of dormancy and anaerobic metabolism to maintain their stemness throughout life. However, with age, changes occur in the pool of HSCs that negatively affect haematopoiesis and the effectiveness of immunity. Niche aging and accumulation of mutations with age reduces the ability of HSCs to self-renew and changes their differentiation potential. This is accompanied by a decrease in clonal diversity and a disturbance of lymphopoiesis (decrease in the formation of naive T- and B-cells) and the predominance of myeloid haematopoiesis. Aging also affects mature cells, regardless of HSC, therefore, phagocytic activity and the intensity of the oxidative burst decrease, and the efficiency of processing and presentation of antigens by myeloid cells is impaired. Aging cells of innate and adaptive immunity produce factors that form a chronic inflammatory background. All these processes have a serious negative impact on the protective properties of the immune system, increasing inflammation, the risk of developing autoimmune, oncological, and cardiovascular diseases with age. Understanding the mechanisms of reducing the regenerative potential in a comparative analysis of embryonic and aging HSCs, the features of inflammatory aging will allow us to get closer to deciphering the programs for the development, aging, regeneration and rejuvenation of HSCs and the immune system.

Indexed as

Cellular SenescenceHematopoietic Stem CellsCell DifferentiationImmune Systemagingaging biomarkershaematopoietic clonalityhaematopoietic hierarchyhematopoietic stem cellsHSCHSC precursorsimmune agingimmune senescenceinflammationpre-HSC

Identifiers

PMID36982935
PMCPMC10056303
OpenAlexW4327957095

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.