Local Liver Irradiation Concurrently Versus Sequentially with Cabozantinib on the Pharmacokinetics and Biodistribution in Rats.

Yu-Chuen Huang, Pei-Ying Hsieh, Li-Ying Wang, Tung-Hu Tsai, Yu-Jen Chen, Chen-Hsi Hsieh

Open access · goldAbstract read

In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.4field-weighted citation impact, top 39% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Yu-Chuen HuangDepartment of Medical Research, China Medical University Hospital, Taichung 404, Taiwan.

Pei-Ying HsiehDepartment of Oncology and Hematology, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan.ORCID 0000-0003-2224-4922

Li-Ying WangSchool and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Taipei 100, Taiwan.

Tung-Hu TsaiInstitute of Traditional Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.ORCID 0000-0002-9007-2547

Yu-Jen ChenDepartment of Medical Research, China Medical University Hospital, Taichung 404, Taiwan.ORCID 0000-0001-9794-8938

Chen-Hsi HsiehInstitute of Traditional Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.ORCID 0000-0003-0279-4695

National Yang Ming Chiao Tung University · TWChina Medical University · TWFar Eastern Memorial Hospital · TWNational Taiwan University · TW

Funding

MOST, Taiwan MOST 110-2314-B-418-006NYMU-FEMH Joint Research Program 111DN32

6 · The paper itself

Abstract

The aim of this study was to evaluate the radiotherapy (RT)-pharmacokinetics (PK) effect of cabozantinib in concurrent or sequential regimens with external beam radiotherapy (EBRT) or stereotactic body radiation therapy (SBRT). Concurrent and sequential regimens involving RT and cabozantinib were designed. The RT-drug interactions of cabozantinib under RT were confirmed in a free-moving rat model. The drugs were separated on an Agilent ZORBAX SB-phenyl column with a mobile phase consisting of 10 mM potassium dihydrogen phosphate (KH

Indexed as

RadiosurgeryAnimalsCombined Modality TherapyLiverRatsTissue Distributionbiodistributioncabozantinibhepatocellular carcinomapharmacokineticsradiotherapy

Identifiers

PMID36982920

DOI10.3390/ijms24065849

PMCPMC10056485

OpenAlexW4327962132

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.