Evidence map›Paper›PMID 36982877›Full record

ArticleInternational journal of molecular sciences2023

Electrochemical Immunosensor for the Determination of Antibodies against Prostate-Specific Antigen Based on ZnO Nanostructures.

Viktorija Liustrovaite, Dovydas Karoblis, Benediktas Brasiunas, Anton Popov, Arturas Katelnikovas, Aivaras Kareiva, Arunas Ramanavicius, Roman Viter, Maria Teresa Giardi, Donats Erts and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Viktorija LiustrovaiteNanoTechnas-Center of Nanotechnology and Materials Science, Institute of Chemistry, Faculty of Chemistry and Geosciences, Vilnius University, Naugarduko St. 24, LT-03225 Vilnius, Lithuania.
Dovydas KaroblisNanoTechnas-Center of Nanotechnology and Materials Science, Institute of Chemistry, Faculty of Chemistry and Geosciences, Vilnius University, Naugarduko St. 24, LT-03225 Vilnius, Lithuania.ORCID 0000-0001-5022-2515
Benediktas BrasiunasNanoTechnas-Center of Nanotechnology and Materials Science, Institute of Chemistry, Faculty of Chemistry and Geosciences, Vilnius University, Naugarduko St. 24, LT-03225 Vilnius, Lithuania.
Anton PopovNanoTechnas-Center of Nanotechnology and Materials Science, Institute of Chemistry, Faculty of Chemistry and Geosciences, Vilnius University, Naugarduko St. 24, LT-03225 Vilnius, Lithuania.ORCID 0000-0002-9867-1931
Arturas KatelnikovasInstitute of Chemistry, Vilnius University, Naugarduko St. 24, LT-03225 Vilnius, Lithuania.ORCID 0000-0002-3295-8366
Aivaras KareivaInstitute of Chemistry, Vilnius University, Naugarduko St. 24, LT-03225 Vilnius, Lithuania.ORCID 0000-0002-9375-7226
Arunas RamanaviciusNanoTechnas-Center of Nanotechnology and Materials Science, Institute of Chemistry, Faculty of Chemistry and Geosciences, Vilnius University, Naugarduko St. 24, LT-03225 Vilnius, Lithuania.ORCID 0000-0002-0885-3556
Roman ViterInstitute of Atomic Physics and Spectroscopy, University of Latvia, Jelgavas St. 3, LV-1004 Riga, Latvia.
Maria Teresa GiardiInstitute of Crystallography, National Research Council, AdR1, 00010 Montelibretti, Italy.ORCID 0000-0002-7401-5905
Donats ErtsInstitute of Chemical Physics, University of Latvia, 19 Raina Blvd., LV-1586 Riga, Latvia.ORCID 0000-0003-0345-8845
Almira RamanavicieneNanoTechnas-Center of Nanotechnology and Materials Science, Institute of Chemistry, Faculty of Chemistry and Geosciences, Vilnius University, Naugarduko St. 24, LT-03225 Vilnius, Lithuania.ORCID 0000-0001-5864-0359
Vilnius University · LTUniversity of Latvia · LVBiosensor (Italy) · IT

Funding

European Union 778157 CanBioSe
6 · The paper itself

Abstract

In this study, ZnO nanostructures with different types of morphologies and particle sizes were evaluated and applied for the development of an immunosensor. The first material was composed of spherical, polydisperse nanostructures with a particle size in the range of 10-160 nm. The second was made up of more compact rod-like spherical nanostructures with the diameter of these rods in the range of 50-400 nm, and approximately 98% of the particles were in the range of 20-70 nm. The last sample of ZnO was made up of rod-shaped particles with a diameter of 10-80 nm. These ZnO nanostructures were mixed with Nafion solution and drop-casted onto screen-printed carbon electrodes (SPCE), followed by a further immobilization of the prostate-specific antigen (PSA). The affinity interaction of PSA with monoclonal antibodies against PSA (anti-PSA) was evaluated using the differential pulse voltammetry technique. The limit of detection and limit of quantification of anti-PSA were determined as 1.35 nM and 4.08 nM for compact rod-shaped spherical ZnO nanostructures, and 2.36 nM and 7.15 nM for rod-shaped ZnO nanostructures, respectively.

Indexed as

Biosensing TechniquesZinc OxideAntibodies, MonoclonalElectrochemical TechniquesElectrodesGoldHumansImmunoassayLimit of DetectionMaleMetal NanoparticlesProstate-Specific AntigenAntibodies, MonoclonalGoldProstate-Specific AntigenZinc Oxideantigen–antibody complexcyclic voltammetrydifferential pulse voltammetryelectrochemical immunosensorone-dimensional nanostructureszinc oxide nanostructures

Identifiers

PMID36982877
PMCPMC10052783
OpenAlexW4327969056

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.