Evidence map›Paper›PMID 36982866›Full record

SynthesisInternational journal of molecular sciences2023

Neuroinflammation in Parkinson's Disease: From Gene to Clinic: A Systematic Review.

Carlos Castillo-Rangel, Gerardo Marin, Karla Aketzalli Hernández-Contreras, Micheel Merari Vichi-Ramírez, Cristofer Zarate-Calderon, Osvaldo Torres-Pineda, Dylan L Diaz-Chiguer, David De la Mora González, Erick Gómez Apo, Javier Alejandro Teco-Cortes and 6 more

Abstract readSystematic Review
In one paragraph

Synthesis in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Article
  2. Lack of Association BetweenInternational journal of molecular sciences · 2026
    Article
  3. Article
  4. Review
  5. TREM2 in neurodegeneration and diseases.Molecular psychiatry · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Food science & nutrition · 2025
    Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Association Between Common Variants in theInternational journal of molecular sciences · 2024
    Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Carlos Castillo-RangelNeurosurgery Department, "Hospital Regional 1° de Octubre", Institute of Social Security and Services for State Workers (ISSSTE), México City 07300, Mexico.
Gerardo MarinNeural Dynamics and Modulation Lab, Cleveland Clinic, Cleveland, OH 44195, USA.
Karla Aketzalli Hernández-ContrerasBrain Research Institute, Universidad Veracruzana, Xalapa 91192, Mexico.
Micheel Merari Vichi-RamírezBrain Research Institute, Universidad Veracruzana, Xalapa 91192, Mexico.ORCID 0000-0003-0434-4030
Cristofer Zarate-CalderonBrain Research Institute, Universidad Veracruzana, Xalapa 91192, Mexico.ORCID 0000-0002-6039-3745
Osvaldo Torres-PinedaBrain Research Institute, Universidad Veracruzana, Xalapa 91192, Mexico.ORCID 0000-0002-8937-4433
Dylan L Diaz-ChiguerNeurosurgery Department, "Hospital Regional 1° de Octubre", Institute of Social Security and Services for State Workers (ISSSTE), México City 07300, Mexico.
David De la Mora GonzálezBrain Research Institute, Universidad Veracruzana, Xalapa 91192, Mexico.
Erick Gómez ApoPathology Department, "Hospital General de México", Dr. Eduardo Liceaga, México City 06720, Mexico.
Javier Alejandro Teco-CortesPathology Department, "Hospital General de México", Dr. Eduardo Liceaga, México City 06720, Mexico.
Flor de María Santos-PaezBrain Research Institute, Universidad Veracruzana, Xalapa 91192, Mexico.ORCID 0000-0003-0707-9957
María de Los Ángeles Coello-TorresResearch Department, "Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran", México City 14080, Mexico.
Matías BaldonciniLaboratory of Microsurgical Neuroanatomy, Second Chair of Gross Anatomy, University of Buenos Aires, Buenos Aires C1052AAA, Argentina.ORCID 0000-0001-9323-8306
Gervith Reyes SotoNational Cancer Institute (INCAN), México City 14080, Mexico.
Gonzalo Emiliano Aranda-AbreuBrain Research Institute, Universidad Veracruzana, Xalapa 91192, Mexico.ORCID 0000-0001-8519-5473
Luis I GarcíaBrain Research Institute, Universidad Veracruzana, Xalapa 91192, Mexico.ORCID 0000-0001-6967-1919

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease is a neurodegenerative disease whose progression and clinical characteristics have a close bidirectional and multilevel relationship with the process of neuroinflammation. In this context, it is necessary to understand the mechanisms involved in this neuroinflammation-PD link. This systematic search was, hereby, conducted with a focus on the four levels where alterations associated with neuroinflammation in PD have been described (genetic, cellular, histopathological and clinical-behavioral) by consulting the PubMed, Google Scholar, Scielo and Redalyc search engines, including clinical studies, review articles, book chapters and case studies. Initially, 585,772 articles were included, and, after applying the inclusion and exclusion criteria, 84 articles were obtained that contained information about the multilevel association of neuroinflammation with alterations in gene, molecular, cellular, tissue and neuroanatomical expression as well as clinical-behavioral manifestations in PD.

Indexed as

Neurodegenerative DiseasesParkinson DiseaseHumansNeuroinflammatory Diseasescellular alterationsclinical manifestationsgene expressionmolecular pathwaysneuroanatomical alterationsneurobehavioralParkinson’s disease

Identifiers

PMID36982866
PMCPMC10051221

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.