Evidence map›Paper›PMID 36982865›Full record

ReviewInternational journal of molecular sciences2023

Intracellular Membrane Transport in Vascular Endothelial Cells.

Alexander A Mironov, Anna Mironov, Barbara Sanavio, Silke Krol, Galina V Beznoussenko

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Regeneration of Vascular Endothelium in Different Large Vessels.International journal of molecular sciences · 2025
    Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Endothelial Dysfunction in Diabetes Mellitus: New Insights.International journal of molecular sciences · 2023
    Review
  13. Understanding the Golgi Apparatus and Intracellular Transport Pathways.International journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Alexander A MironovThe AIRC Institute of Molecular Oncology, 20139 Milan, Italy.ORCID 0000-0003-2308-1651
Anna MironovSacco Hospital, Universita degli Studi di Milano, 20122 Milan, Italy.
Barbara SanavioNanomedicine Laboratory, Fondazione IRCCS Istituto Neurologico Carlo Besta, c/o AMADEOLAB, 20133 Milan, Italy.ORCID 0000-0001-5837-4097
Silke KrolEncytos BV, 7511 JE Enschede, The Netherlands.
Galina V BeznoussenkoThe AIRC Institute of Molecular Oncology, 20139 Milan, Italy.
University of Milan · ITIFOM · ITUniversity of Twente · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The main component of blood and lymphatic vessels is the endothelium covering their luminal surface. It plays a significant role in many cardiovascular diseases. Tremendous progress has been made in deciphering of molecular mechanisms involved into intracellular transport. However, molecular machines are mostly characterized in vitro. It is important to adapt this knowledge to the situation existing in tissues and organs. Moreover, contradictions have accumulated within the field related to the function of endothelial cells (ECs) and their trans-endothelial pathways. This has induced necessity for the re-evaluation of several mechanisms related to the function of vascular ECs and intracellular transport and transcytosis there. Here, we analyze available data related to intracellular transport within ECs and re-examine several hypotheses about the role of different mechanisms in transcytosis across ECs. We propose a new classification of vascular endothelium and hypotheses related to the functional role of caveolae and mechanisms of lipid transport through ECs.

Indexed as

Endothelial CellsTranscytosisBiological TransportCaveolaeEndothelium, VascularIntracellular Membranesendothelial cellsintracellular transportintra-Golgi transportmicropinocytic vesiclesthe Golgi complexthe kiss-and-run modeltranscytosis across endothelial cellsvesicular–vacuolar organelle

Identifiers

PMID36982865
PMCPMC10059831
OpenAlexW4327968485

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.