Evidence map›Paper›PMID 36982859›Full record

ArticleInternational journal of molecular sciences2023

Molecular Mechanisms Underlying TNFα-Induced Mitochondrial Biogenesis in Human Airway Smooth Muscle.

Debanjali Dasgupta, Sanjana Mahadev Bhat, Alexis L Price, Philippe Delmotte, Gary C Sieck

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Molecular mechanisms underlying FCCP-induced mitophagy in human airway smooth muscle cells.American journal of physiology. Lung cellular and molecular physiology · 2026
    Article
  3. Article
  4. AhR activation inhibits DRP1-induced mitochondrial fission in airway smooth muscle during asthma.American journal of respiratory cell and molecular biology · 2026
    Article
  5. Tumor necrosis factor α-induced endoplasmic reticulum stress promotes airway smooth muscle cell proliferation.American journal of physiology. Lung cellular and molecular physiology · 2026
    Article
  6. Review
  7. Review
  8. Article
  9. TNFα-mediated subcellular heterogeneity of succinate dehydrogenase activity in human airway smooth muscle cells.American journal of physiology. Lung cellular and molecular physiology · 2025
    Article
  10. Review
  11. Article
  12. Article
  13. Molecular mechanisms underlying TNFα-induced mitochondrial fragmentation in human airway smooth muscle cells.American journal of physiology. Lung cellular and molecular physiology · 2024
    Article
  14. Energy Regulation in Inflammatory Sarcopenia by the Purinergic System.International journal of molecular sciences · 2023
    Review
  15. Article
  16. Article
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Debanjali DasguptaDepartment of Physiology & Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0001-8307-9719
Sanjana Mahadev BhatDepartment of Physiology & Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0002-7597-9597
Alexis L PriceDepartment of Physiology & Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.
Philippe DelmotteDepartment of Physiology & Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0003-1285-6554
Gary C SieckDepartment of Physiology & Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0003-3040-9424
Mayo Clinic in Florida · US

Funding

Impact of Airway Inflammation on MitochondriaR01HL157984 · NHLBI · MAYO CLINIC ROCHESTER · PI PRAKASH, Y. S., SIECK, GARY C. · 2021 to 2024
$2.7M
Role of Mitochondria in Airway Smooth MuscleR01HL126451 · NHLBI · MAYO CLINIC ROCHESTER · PI PRAKASH, Y. S., SIECK, GARY C. · 2015 to 2018
$1.9M
NHLBI NIH HHS R01 HL126451NHLBI NIH HHS R01 HL157984NIH HHS HL157984
6 · The paper itself

Abstract

Proinflammatory cytokines such as TNFα mediate airway inflammation. Previously, we showed that TNFα increases mitochondrial biogenesis in human ASM (hASM) cells, which is associated with increased PGC1α expression. We hypothesized that TNFα induces CREB and ATF1 phosphorylation (pCREB

Indexed as

Organelle BiogenesisTumor Necrosis Factor-alphaDNA, MitochondrialHumansMitochondriaMitochondrial ProteinsMuscle, SmoothPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaDNA, MitochondrialMitochondrial ProteinsPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaTumor Necrosis Factor-alphaairway inflammationATF1CREBmitochondrial biogenesismtDNANRFsPGC1αTNFα

Identifiers

PMID36982859
PMCPMC10055892
OpenAlexW4327969102

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.