Evidence map›Paper›PMID 36982774›Full record

ArticleInternational journal of molecular sciences2023

Giulia Cappelli, Daniela Giovannini, Laura Vilardo, Annalisa Basso, Ilaria Iannetti, Marianna Massa, Giuseppe Ruberto, Ryan Muir, Carlo Pastore, Igea D'Agnano and 1 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07482423 (A Phase I/II Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Safety and Potential Efficacy of XVIE Injected Intradermally in Patients With Androgenetic Alopecia), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07482423 phase1 / phase2not yet recruitingnot on this mapstarted 2026, after this paper: background citation

A Phase I/II Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Safety and Potential Efficacy of XVIE Injected Intradermally in Patients With Androgenetic Alopecia

TypeinterventionalSponsorRestore Biologics Holdings, Inc. dba XtresséRan2026 to 2028Enrolled30ConditionsAndrogenetic AlopeciaArmsDecellularized allogeneic human amniotic fluid, Sodium chloride 0.9% injectable solution
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Selective cytotoxicity ofFrontiers in pharmacology · 2025
    Article
  5. Review
  6. Spicing Up Meat Preservation:Foods (Basel, Switzerland) · 2024
    Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Giulia CappelliInstitute for Biological Systems (ISB)-CNR, Via Salaria Km 29, 00015 Monterotondo, Italy.
Daniela GiovanniniInstitute of Biochemistry and Cell Biology (IBBC)-CNR, Via E. Ramarini 32, 00015 Monterotondo, Italy.
Laura VilardoInstitute for Biomedical Technologies (ITB)-CNR, Via Fratelli Cervi 93, 20054 Segrate, Italy.
Annalisa BassoInstitute of Biochemistry and Cell Biology (IBBC)-CNR, Via E. Ramarini 32, 00015 Monterotondo, Italy.
Ilaria IannettiInstitute of Biochemistry and Cell Biology (IBBC)-CNR, Via E. Ramarini 32, 00015 Monterotondo, Italy.
Marianna MassaInstitute of Biochemistry and Cell Biology (IBBC)-CNR, Via E. Ramarini 32, 00015 Monterotondo, Italy.
Giuseppe RubertoInstitute for Biochemical Chemistry (ICB)-CNR, Via Paolo Gaifami, 18, 95126 Catania, Italy.ORCID 0000-0002-6610-6110
Ryan MuirDepartment of Pharmaceutical Chemistry, University of California, UCSF Byers Hall MC2552, San Francisco, CA 94158, USA.
Carlo PastoreSanatrix Clinic, Via di Trasone 61, 00199 Rome, Italy.
Igea D'AgnanoInstitute for Biomedical Technologies (ITB)-CNR, Via Fratelli Cervi 93, 20054 Segrate, Italy.ORCID 0000-0002-2646-9224
Francesca MarianiInstitute for Biological Systems (ISB)-CNR, Via Salaria Km 29, 00015 Monterotondo, Italy.ORCID 0000-0002-5616-6566
Institute of Cell Biology and Neurobiology · ITInstitute for Biological SystemsInstitute of Biomedical Technologies · ITIstituto di Chimica Biomolecolare · ITUniversity of California, San Francisco · US

Funding

National Research Council NutrAge (project nr. 7022).
6 · The paper itself

Abstract

Given the known pro-oxidant status of tumour cells, the development of anti-proliferative strategies focuses on products with both anti- and pro-oxidant properties that can enhance antitumour drug cytotoxicity. We used a

Indexed as

MelanomaOils, VolatileCell Line, TumorCell ProliferationCinnamomum zeylanicumFerrous CompoundsHumansReactive Oxygen SpeciesFerrous CompoundsOils, VolatileReactive Oxygen Speciesantioxidant responsebotanicalsC. zeylanicumferrous ironhuman melanoma

Identifiers

PMID36982774
PMCPMC10058067
OpenAlexW4327715958

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.